Brain circuits for pain and its treatment
Pain is a multidimensional experience with sensory-discriminative, affective-motivational,
and cognitive-evaluative components. Pain aversiveness is one principal cause of suffering …
and cognitive-evaluative components. Pain aversiveness is one principal cause of suffering …
Neuromorphic hardware for somatosensory neuroprostheses
In individuals with sensory-motor impairments, missing limb functions can be restored using
neuroprosthetic devices that directly interface with the nervous system. However, restoring …
neuroprosthetic devices that directly interface with the nervous system. However, restoring …
Low-threshold, high-resolution, chronically stable intracortical microstimulation by ultraflexible electrodes
Intracortical microstimulation (ICMS) enables applications ranging from neuroprosthetics to
causal circuit manipulations. However, the resolution, efficacy, and chronic stability of …
causal circuit manipulations. However, the resolution, efficacy, and chronic stability of …
Activity-dependent recruitment of inhibition and excitation in the awake mammalian cortex during electrical stimulation
Electrical stimulation is an effective tool for mapping and altering brain connectivity, with
applications ranging from treating pharmacology-resistant neurological disorders to …
applications ranging from treating pharmacology-resistant neurological disorders to …
In vivo spatiotemporal dynamics of astrocyte reactivity following neural electrode implantation
Brain computer interfaces (BCIs), including penetrating microelectrode arrays, enable both
recording and stimulation of neural cells. However, device implantation inevitably causes …
recording and stimulation of neural cells. However, device implantation inevitably causes …
Dynamic amplitude modulation of microstimulation evokes biomimetic onset and offset transients and reduces depression of evoked calcium responses in sensory …
Background Intracortical microstimulation (ICMS) is an emerging approach to restore
sensation to people with neurological injury or disease. Biomimetic microstimulation, or …
sensation to people with neurological injury or disease. Biomimetic microstimulation, or …
Neural plasticity in sensorimotor brain–machine interfaces
MC Dadarlat, RA Canfield… - Annual review of …, 2023 - annualreviews.org
Brain–machine interfaces (BMIs) aim to treat sensorimotor neurological disorders by
creating artificial motor and/or sensory pathways. Introducing artificial pathways creates new …
creating artificial motor and/or sensory pathways. Introducing artificial pathways creates new …
Cell-specific alterations in autophagy-lysosomal activity near the chronically implanted microelectrodes
Intracortical microelectrodes that can record and stimulate brain activity have become a
valuable technique for basic science research and clinical applications. However, long-term …
valuable technique for basic science research and clinical applications. However, long-term …
Activation and depression of neural and hemodynamic responses induced by the intracortical microstimulation and visual stimulation in the mouse visual cortex
N Suematsu, AL Vazquez… - Journal of Neural …, 2024 - iopscience.iop.org
Objective. Intracortical microstimulation (ICMS) can be an effective method for restoring
sensory perception in contemporary brain–machine interfaces. However, the mechanisms …
sensory perception in contemporary brain–machine interfaces. However, the mechanisms …
Intracortical microstimulation pulse waveform and frequency recruits distinct spatiotemporal patterns of cortical neuron and neuropil activation
Objective. Neural prosthetics often use intracortical microstimulation (ICMS) for sensory
restoration. To restore natural and functional feedback, we must first understand how …
restoration. To restore natural and functional feedback, we must first understand how …