Phospholipase A2 Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention
1.1. Discovery of the Phospholipase A2 Superfamily Phospholipases represent one of the
earliest enzyme activities to be identified and studied, and the phospholipase A2 (PLA2) …
earliest enzyme activities to be identified and studied, and the phospholipase A2 (PLA2) …
Molecular mechanisms of necroptosis: an ordered cellular explosion
P Vandenabeele, L Galluzzi… - … reviews Molecular cell …, 2010 - nature.com
For a long time, apoptosis was considered the sole form of programmed cell death during
development, homeostasis and disease, whereas necrosis was regarded as an unregulated …
development, homeostasis and disease, whereas necrosis was regarded as an unregulated …
[HTML][HTML] Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction
JR Tribble, A Otmani, S Sun, SA Ellis, G Cimaglia… - Redox biology, 2021 - Elsevier
Nicotinamide adenine dinucleotide (NAD) is a REDOX cofactor and metabolite essential for
neuronal survival. Glaucoma is a common neurodegenerative disease in which neuronal …
neuronal survival. Glaucoma is a common neurodegenerative disease in which neuronal …
[HTML][HTML] Cytosolic phospholipase A2: physiological function and role in disease
CC Leslie - Journal of lipid research, 2015 - ASBMB
The group IV phospholipase A 2 (PLA 2) family is comprised of six intracellular enzymes
(GIVA,-B,-C,-D,-E, and-F) commonly referred to as cytosolic PLA 2 (cPLA 2) α,-β,-γ,-δ,-ε, and …
(GIVA,-B,-C,-D,-E, and-F) commonly referred to as cytosolic PLA 2 (cPLA 2) α,-β,-γ,-δ,-ε, and …
Lipoxygenase and leukotriene pathways: biochemistry, biology, and roles in disease
JZ Haeggstrom, CD Funk - Chemical reviews, 2011 - ACS Publications
Metabolism of arachidonic acid leads to several families of lipid mediators, including
prostaglandins, thromboxane, leukotrienes, and lipoxins, along two major metabolic …
prostaglandins, thromboxane, leukotrienes, and lipoxins, along two major metabolic …
Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation
Phospholipase A2 (PLA2) enzymes are considered the primary source of arachidonic acid
for cyclooxygenase (COX)–mediated biosynthesis of prostaglandins. Here, we show that a …
for cyclooxygenase (COX)–mediated biosynthesis of prostaglandins. Here, we show that a …
[HTML][HTML] The anti-inflammatory effects of vitamin D in tumorigenesis
W Liu, L Zhang, HJ Xu, Y Li, CM Hu, JY Yang… - International journal of …, 2018 - mdpi.com
In conjunction with the classical functions of regulating intestinal, bone, and kidney calcium
and phosphorus absorption, as well as bone mineralization of vitamin D, the population …
and phosphorus absorption, as well as bone mineralization of vitamin D, the population …
Cyclooxygenases: structural, cellular, and molecular biology
WL Smith, DL DeWitt, RM Garavito - Annual review of …, 2000 - annualreviews.org
▪ Abstract The prostaglandin endoperoxide H synthases-1 and 2 (PGHS-1 and PGHS-2; also
cyclooxygenases-1 and 2, COX-1 and COX-2) catalyze the committed step in prostaglandin …
cyclooxygenases-1 and 2, COX-1 and COX-2) catalyze the committed step in prostaglandin …
Prostanoid receptors: structures, properties, and functions
S Narumiya, Y Sugimoto… - Physiological reviews, 1999 - journals.physiology.org
Prostanoids are the cyclooxygenase metabolites of arachidonic acid and include
prostaglandin (PG) D2, PGE2, PGF2α, PGI2, and thromboxne A2. They are synthesized and …
prostaglandin (PG) D2, PGE2, PGF2α, PGI2, and thromboxne A2. They are synthesized and …
Enzyme inhibitor discovery by activity-based protein profiling
MJ Niphakis, BF Cravatt - Annual review of biochemistry, 2014 - annualreviews.org
Eukaryotic and prokaryotic organisms possess huge numbers of uncharacterized enzymes.
Selective inhibitors offer powerful probes for assigning functions to enzymes in native …
Selective inhibitors offer powerful probes for assigning functions to enzymes in native …