Introduction Leishmaniasis is a neglected tropical infectious disease. The available limited
therapeutic options for leishmaniasis are inadequate due to their poor pharmacokinetic …

Leishmaniasis, which is caused by a parasitic protozoan of the genus Leishmania, is still a
major threat to global health, impacting millions of individuals worldwide in endemic areas …

Abstract Quinoline and 1, 2, 3-triazoles are well-known nitrogen-based heterocycles
presenting diverse pharmacological properties, although their antileishmanial activity is still …

Leishmaniasis and Chagas disease, two of the most prevalent neglected tropical diseases,
are a world health problem. The harsh reality of these infective diseases is the absence of …

Current therapies of leishmaniasis and Chagas disease, two of the most widespread
neglected tropical diseases, have limited efficacy and toxic side effects. In this regard …

For decades, only two nitroheterocyclic drugs have been used as therapeutic agents for
Chagas disease. However, these drugs present limited effectiveness during the chronic …

Leishmaniasis and Chagas disease affect millions of people worldwide. The available
treatments against these parasitic diseases are limited and display multiple undesired …

Antileishmanial chemotherapy is currently limited due to severe toxic side effects and drug
resistance. Hence, new antileishmanial compounds based on alternative approaches …

Leishmaniasis and Chagas disease are neglected tropical diseases that cause problems in
developing countries. The causative agents, Leishmania spp. and Trypanosoma cruzi …

Oncogene-induced tumorigenesis results in the variation of epigenetic modifications, and in
addition to promoting cell immortalization, cancer cells undergo more intense cellular stress …