Aqueous solubility is one of the major challenges in the early stages of drug discovery. One
of the most common and effective methods for enhancing solubility is the addition of an …

The equilibrium 5-nitrosalicylaldehyde solubility in methanol (1)+ water (2), ethanol (1)+
water (2), isopropanol (1)+ water (2) and acetonitrile (1)+ water (2) mixtures was determined …

A continuous tubular crystallizer system with an inner diameter of 2.0 mm and an overall
length of 27 m was used to generate acetylsalicylic acid seeds in situ from ethanolic solution …

A continuously operated tubular crystallizer system with an inner diameter of 2.0 mm has
been successfully operated. It allows the crystallization of active pharmaceutical ingredients …

The mole fraction solubility of amoxicillin in four co-solvent mixtures of N, N-
dimethylformamide (DMF)+ water (2), isopropanol (1)+ water (2), N-methyl pyrrolidone …

Nanoindentation enables the measurement of mechanical properties from single crystals
with dimensions of a few micrometers. This experimental technique, however, has only …

This study investigates the effects of seed loading on the mean crystal size of the model
substance, acetylsalicylic acid, crystallized from ethanol in a continuously seeded tubular …

While large-scale crystallizer design profits from many years of accumulated knowledge,
traditional fabrication technologies limit the possibilities for easy and rapid lab-scale design …

The equilibrium solubility of curcumin in solvent mixtures of ethanol (1)+ water (2), n-
propanol (1)+ water (2), isopropanol (1)+ water (2) and propylene glycol (PG, 1)+ water (2) …

Besides size and polymorphic form, crystal shape takes a central role in engineering
advanced solid materials for the pharmaceutical and chemical industries. This work …