The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to
societies and economies. Until now, effective therapeutics against COVID-19 are in high …

Appropriate selection and correct use of inhalation devices is an integral component in the
management of asthma and chronic obstructive pulmonary disease (COPD). It is well known …

Asthma is a common chronic inflammatory disorder of the lower respiratory airways in
childhood. The management of asthma exacerbations and the disease control are major …

Inhaled therapies are the cornerstone of treatment in asthma and chronic obstructive
pulmonary disease, and there are a multitude of devices available. There is, however, a …

Background The involvement of small airways has recently gained greater recognition in
asthma. Impulse oscillometry (IOS) is a simple and noninvasive method based on the forced …

For more than 50 years, small airways disease has been considered a key feature of chronic
obstructive pulmonary disease (COPD) and a major cause of airway obstruction. Both …

Background The small-airway dysfunction (SAD), detected with impulse oscillometry (IOS)
methods, has been recently better characterized in patients with asthma. However, little is …

Inhaled glucocorticoids (GCs) are drugs widely used as treatment for asthma patients. They
prevent the recruitment and activation of lung immune and inflammatory cells and …

Identification of pathologic changes in early and mild obstructive lung disease has shown
the importance of the small airways and their contribution to symptoms. Indeed, significant …

Asthma is a chronic disease, affecting approximately 350 million people worldwide.
Inflammation and remodeling in asthma involve the large airways, and it is now widely …