Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease
Biobanks facilitate genome-wide association studies (GWASs), which have mapped
genomic loci across a range of human diseases and traits. However, most biobanks are …
genomic loci across a range of human diseases and traits. However, most biobanks are …
Harnessing Artificial Intelligence in Multimodal Omics Data Integration: Paving the Path for the Next Frontier in Precision Medicine
The integration of multiomics data with detailed phenotypic insights from electronic health
records marks a paradigm shift in biomedical research, offering unparalleled holistic views …
records marks a paradigm shift in biomedical research, offering unparalleled holistic views …
From pharmacogenetics to pharmaco-omics: Milestones and future directions
The origins of pharmacogenetics date back to the 1950s, when it was established that inter-
individual differences in drug response are partially determined by genetic factors. Since …
individual differences in drug response are partially determined by genetic factors. Since …
Cross-ancestry investigation of venous thromboembolism genomic predictors
Background: Venous thromboembolism (VTE) is a life-threatening vascular event with
environmental and genetic determinants. Recent VTE genome-wide association studies …
environmental and genetic determinants. Recent VTE genome-wide association studies …
A robust cis-Mendelian randomization method with application to drug target discovery
Z Lin, W Pan - Nature Communications, 2024 - nature.com
Mendelian randomization (MR) uses genetic variants as instrumental variables (IVs) to
investigate causal relationships between traits. Unlike conventional MR, cis-MR focuses on …
investigate causal relationships between traits. Unlike conventional MR, cis-MR focuses on …
Statistically and functionally fine-mapped blood eQTLs and pQTLs from 1,405 humans reveal distinct regulation patterns and disease relevance
QS Wang, T Hasegawa, H Namkoong, R Saiki… - Nature Genetics, 2024 - nature.com
Studying the genetic regulation of protein expression (through protein quantitative trait loci
(pQTLs)) offers a deeper understanding of regulatory variants uncharacterized by mRNA …
(pQTLs)) offers a deeper understanding of regulatory variants uncharacterized by mRNA …
A practical guideline of genomics-driven drug discovery in the era of global biobank meta-analysis
Genomics-driven drug discovery is indispensable for accelerating the development of novel
therapeutic targets. However, the drug discovery framework based on evidence from …
therapeutic targets. However, the drug discovery framework based on evidence from …
Genetic associations of circulating cardiovascular proteins with gestational hypertension and preeclampsia
Importance Hypertensive disorders of pregnancy (HDPs), including gestational hypertension
and preeclampsia, are important contributors to maternal morbidity and mortality worldwide …
and preeclampsia, are important contributors to maternal morbidity and mortality worldwide …
Best practices for multi-ancestry, meta-analytic transcriptome-wide association studies: lessons from the Global Biobank Meta-analysis Initiative
Summary The Global Biobank Meta-analysis Initiative (GBMI), through its diversity, provides
a valuable opportunity to study population-wide and ancestry-specific genetic associations …
a valuable opportunity to study population-wide and ancestry-specific genetic associations …
Application of proteomics for novel drug discovery and risk prediction optimisation in stroke and myocardial infarction: a review of in-human studies
The use of proteomics in human studies investigating stroke and myocardial infarction (MI)
has been increasing, prompting a review of the literature. This revealed proteinaceous …
has been increasing, prompting a review of the literature. This revealed proteinaceous …