Melanoma is recognized as the most dangerous type of skin cancer, with high mortality and
resistance to currently used treatments. To overcome the limitations of the available …

Melanoma is an aggressive form of skin cancer, being one of the deadliest cancers in the
world. The current treatment options involve surgery, radiotherapy, targeted therapy …

Among the human copper-containing monooxygenases, Tyrosinase (Ty) is an important
enzyme involved in the determinant step of the biosynthetic pathway of melanin pigment. In …

Background A guanine-rich strand within the promoter of the KRAS gene can fold into an
intra-molecular G-quadruplex structure (G4), which has an important role in the regulation of …

Triazenes are a very useful and diverse class of compounds that have been studied for their
potential in the treatment of many tumors including brain tumor, leukemia and melanoma …

1-Acyl triazenes can be prepared by acid-catalyzed hydration, gold/iodine-catalyzed
oxidation, or oxyhalogenation of 1-alkynyl triazenes. Crystallographic analyses reveal a …

Metastatic melanoma still remains one the most difficult cancers to overcome. The aim of our
research was the design of anti-tumour triazene compounds 3 for application to a melanoma …

Malignant melanoma is the major cause of death from skin cancer. Treatment of metastatic
melanoma remains an enormous challenge. In this study we developed hybrid compounds …

Dengue fever is an infectious disease caused by the dengue virus (DENV), an RNA
Flavivirus transmitted by the mosquitoes Aedes aegypti and Aedes albopictus widespread in …

Tumor-selective drug delivery could enhance anticancer efficacy and avoid drug side
effects. However, because of tumor heterogeneity, current nanoparticle-based drug delivery …