Current drug therapy and pharmaceutical challenges for Chagas disease

J Bermudez, C Davies, A Simonazzi, JP Real, S Palma - Acta tropica, 2016 - Elsevier
One of the most significant health problems in the American continent in terms of human
health, and socioeconomic impact is Chagas disease, caused by the protozoan parasite …

The use of animal models in homeopathic research–a review of 2010–2014 PubMed indexed papers

LV Bonamin, TN Cardoso, AC de Carvalho… - …, 2015 - thieme-connect.com
Background: In the 1990s, a study was performed on the effects of highly diluted thyroxine
on frog metamorphosis. This model represented one of the most discussed examples of the …

Immune and antioxidant enzyme response of Longfin yellowtail (Seriola rivoliana) juveniles to ultra-diluted substances derived from phosphorus, silica and …

JM Mazón-Suástegui, J Salas-Leiva, A Teles… - …, 2019 - thieme-connect.com
Background This research aimed to observe the effect of homeopathic treatments prepared
from Vibrio parahaemolyticus and V. alginolyticus (H1) and commercial homeopathic …

Modulation of inflammation response to murine cutaneous Leishmaniasis by homeopathic medicines: Antimonium crudum 30cH

FR de Santana, C de Paula Coelho, TN Cardoso… - …, 2014 - thieme-connect.com
Background: Leishmaniasis is a zoonotic disease caused by protozoan parasites of the
mononuclear phagocytic system. The modulation activity of these cells can interfere in the …

[HTML][HTML] Could phenothiazine-benznidazole combined chemotherapy be effective in controlling heart parasitism and acute infectious myocarditis?

AAS Mendonça, E Gonçalves-Santos… - Pharmacological …, 2020 - Elsevier
Phenothiazines inhibit major antioxidant defense mechanisms in trypanosomatids and
exhibit potent cytotoxic effects in vitro. However, the relevance of these drugs in the …

New Drugs and Promising Drug Combinations in the Treatment of Chagas Disease in Brazil: A Systematic Review and Meta-Analysis

ES Freire, LP da Silva, A do Carmo Silva… - Archives of Medical …, 2025 - Elsevier
Chagas disease (CD) is a parasitic infection caused by the protozoan Trypanosoma cruzi
(Kinetoplastida, Trypanosomatidae). Benznidazole (Bz) has a limited ability to interfere with …

Highly diluted medication reduces tissue parasitism and inflammation in mice infected by Trypanosoma cruzi

CR Lopes, GJS Falkowski, CF Brustolin… - …, 2016 - thieme-connect.com
Aim: To evaluate the effects of Kalium causticum, Conium maculatum, and Lycopodium
clavatum 13cH in mice infected by Trypanosoma cruzi. Materials and methods: In a blind …

[HTML][HTML] Thioridazine aggravates skeletal myositis, systemic and liver inflammation in Trypanosoma cruzi-infected and benznidazole-treated mice

AAS Mendonca, E Goncalves-Santos… - International …, 2020 - Elsevier
While thioridazine (Tio) inhibits the antioxidant defenses of Trypanosoma cruzi, the gold
standard antitrypanosomal drug benznidazole (Bz) has potent anti-inflammatory and pro …

Trypanosoma cruzi: biotherapy made from trypomastigote modulates the inflammatory response

P Sandri, DL Aleixo, GJS Falkowski, ADN Júnior… - …, 2015 - thieme-connect.com
This study evaluates the effect of Trypanosoma cruzi biotherapy 17dH (BIOT) on mice of
different ages, infected with the protozoa concerned. Method: Performing a blind, controlled …

The use of a heterogeneously controlled mouse population reveals a significant correlation of acute phase parasitemia with mortality in Chagas disease

TLM Sanches, LD Cunha, GK Silva, PMM Guedes… - PLoS …, 2014 - journals.plos.org
Chagas disease develops upon infection with the protozoan parasite Trypanosoma cruzi
and undergoes an acute phase characterized by massive parasite replication and the …