Naturally produced halogenated compounds are ubiquitous across all domains of life where
they perform a multitude of biological functions and adopt a diversity of chemical structures …

Halohydrin dehalogenases are industrially relevant enzymes that catalyze the reversible
dehalogenation of vicinal haloalcohols with formation of the corresponding epoxides. In the …

Catalytic stereoselective desymmetrization of prochiral compounds to valuable chiral
molecules is of interest in asymmetric synthesis. Here, we report the development of an …

At the moment, there are approx. 100 published papers investigating halohydrin
dehalogenases from different aspects; enzymology, molecular biology and reactions they …

Expanding the enzymatic toolbox for the green synthesis of valuable molecules is still of
high interest in synthetic chemistry and the pharmaceutical industry. Chiral thiiranes are …

The development of catalytic enantioselective cyanation methods for preparing valuable
chiral nitriles is of great interest in the areas of pharmaceutical synthesis and organic …

To improve the applicability of halohydrin dehalogenase as a catalyst for reactions in the
presence of organic cosolvents, we explored a computational library design strategy …

The vanadium-dependent chloroperoxidase from Curvularia inaequalis is a stable and
efficient biocatalyst for the hydroxyhalogenation of a broad range of alkenes into …

Halohydrin dehalogenases are very rare enzymes that are naturally involved in the
mineralization of halogenated xenobiotics. Due to their catalytic potential and promiscuity …

Statins, inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, are the
largest selling class of drugs prescribed for the pharmacological treatment of …