Aβ-oligomers: A potential therapeutic target for Alzheimer's disease
The cascade of amyloid formation relates to multiple complex events at the molecular level.
Previous research has established amyloid plaque deposition as the leading cause of …
Previous research has established amyloid plaque deposition as the leading cause of …
Multi-target drug candidates for multifactorial Alzheimer's disease: AChE and NMDAR as molecular targets
MS Uddin, A Al Mamun, MT Kabir, GM Ashraf… - Molecular …, 2021 - Springer
Alzheimer's disease (AD) is one of the most common forms of dementia among elder
people, which is a progressive neurodegenerative disease that results from a chronic loss of …
people, which is a progressive neurodegenerative disease that results from a chronic loss of …
Amyloid β 42 fibril structure based on small-angle scattering
Amyloid fibrils are associated with a number of neurodegenerative diseases, including fibrils
of amyloid β42 peptide (Aβ42) in Alzheimer's disease. These fibrils are a source of toxicity to …
of amyloid β42 peptide (Aβ42) in Alzheimer's disease. These fibrils are a source of toxicity to …
Oligomerization and conformational change turn monomeric β-amyloid and tau proteins toxic: Their role in Alzheimer's pathogenesis
B Penke, M Szűcs, F Bogár - Molecules, 2020 - mdpi.com
The structural polymorphism and the physiological and pathophysiological roles of two
important proteins, β-amyloid (Aβ) and tau, that play a key role in Alzheimer's disease (AD) …
important proteins, β-amyloid (Aβ) and tau, that play a key role in Alzheimer's disease (AD) …
[HTML][HTML] Neutron reflection and scattering in characterising peptide assemblies
Self-assemblies of de novo designed short peptides at interface and in bulk solution provide
potential platforms for developing applications in many medical and technological areas …
potential platforms for developing applications in many medical and technological areas …
Pyroglutamate-modified amyloid β (3–42) monomer has more β-sheet content than the amyloid β (1–42) monomer
The aggregation of the amyloid β (Aβ) peptide is a major hallmark of Alzheimer's disease.
This peptide can aggregate into oligomers, proto-fibrils and mature fibrils, which eventually …
This peptide can aggregate into oligomers, proto-fibrils and mature fibrils, which eventually …
Overview on the Polyphenol Avenanthramide in Oats (Avena sativa Linn.) as Regulators of PI3K Signaling in the Management of Neurodegenerative Diseases
Avenanthramides (Avns) and their derivatives, a group of polyphenolic compounds found
abundantly in oats (Avena sativa Linn.), have emerged as promising candidates for …
abundantly in oats (Avena sativa Linn.), have emerged as promising candidates for …
Interaction of Aβ42 with membranes triggers the self-assembly into oligomers
The self-assembly of amyloid β (Aβ) proteins into oligomers is the major pathogenic event
leading to Alzheimer's disease (AD). Typical in vitro experiments require high protein …
leading to Alzheimer's disease (AD). Typical in vitro experiments require high protein …
Disclosing the Interaction of Gold Nanoparticles with Aβ (1–40) Monomers through Replica Exchange Molecular Dynamics Simulations
Amyloid-β aggregation is one of the principal causes of amyloidogenic diseases that lead to
the loss of neuronal cells and to cognitive impairments. The use of gold nanoparticles …
the loss of neuronal cells and to cognitive impairments. The use of gold nanoparticles …
[HTML][HTML] Critical aggregation concentration and reversibility of amyloid-β (1–40) oligomers
S Illodo, W Al-Soufi, M Novo - Archives of Biochemistry and Biophysics, 2024 - Elsevier
Amyloid-beta (Aβ) aggregation is a critical factor in the pathogenesis of Alzheimer's disease,
with distinct aggregation behaviours observed between its isoforms Amyloid-β 1–40 (Aβ40) …
with distinct aggregation behaviours observed between its isoforms Amyloid-β 1–40 (Aβ40) …