The heart is a rhythmic electromechanical pump, the functioning of which depends on action
potential generation and propagation, followed by relaxation and a period of refractoriness …

Phosphoinositides serve as signature motifs for different cellular membranes and often are
required for the function of membrane proteins. Here, we summarize clear evidence …

Background—Ex vivo expansion of resident cardiac stem cells, followed by delivery to the
heart, may favor regeneration and functional improvement. Methods and Results …

Calcium regulates a wide spectrum of physiological processes such as heartbeat, muscle
contraction, neuronal communication, hormone release, cell division, and gene …

Unique to striated muscle cells, transverse tubules (t-tubules) are membrane organelles that
consist of sarcolemma penetrating into the myocyte interior, forming a highly branched and …

Voltage-dependent L-type Ca2+ channels are multisubunit transmembrane proteins, which
allow the influx of Ca2+ (I Ca) essential for normal excitability and excitation-contraction …

Loss of cardiac myocytes in heart failure is thought to occur largely through an apoptotic
process. Here we show that heart failure can also be precipitated through myocyte necrosis …

Among the most intriguing forms of Ca 2+ channel modulation is the regulation of L-type and
P/Q-type channels by intracellular Ca 2+, acting via unconventional channel-calmodulin …

The cardiac L-type Ca 2+ channel is a textbook example of an ion channel regulated by
protein phosphorylation; however, the molecular events that underlie its regulation remain …

Sydney Ringer would be overwhelmed today by the implications of his simple experiment
performed over 120 years ago showing that the heart would not beat in the absence of …