Non-healing wounds in Type 2 Diabetes (T2D) patients represent the most common cause
of amputation in the US, with an associated 5-year mortality of nearly 50%. Our lab has …

Diabetes has become a global public health problem. Diabetic foot is one of the most severe
complications of diabetes, which often places a heavy economic burden on patients and …

Diabetic wound healing still faces great challenges due to the excessive inflammation, easy
infection, and impaired angiogenesis in wound beds. The immunoregulation of …

Abstract Sirtuin 3 (SIRT3) is a potential therapeutic target for cardiovascular, metabolic, and
other aging-related diseases. In this study, we investigated the role of SIRT3 in diabetic …

Increasing evidence shows that adipokines play a vital role in the development of
rheumatoid arthritis (RA). Fatty acid-binding protein 4 (FABP4), a novel adipokine that …

Background: Proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors (i) are a class
of lipid-lowering drugs suggested to hold a plethora of beneficial effects independent of their …

M2 polarization of macrophage is an important immunomodulatory event that attenuates
inflammation. To regulate the immune microenvironment in osteoporotic conditions for …

Diabetic wound healing, characterized by chronic inflammation, remains a medical
challenge. The failure of prompt conversion from pro-inflammatory M1-like macrophage to …

Celastrol, a pentacyclic tritepene extracted from Tripterygium Wilfordi plant, showing potent
liver protection effects on several liver‐related diseases. However, the anti‐inflammatory …

Background It is known that hydrogels based on carboxymethyl chitosan (CMCS) have
properties controling microbial growth, reducing inflammatory cell infiltration, and promoting …