The monolayer of endothelial cells lining the vessel wall forms a semipermeable barrier (in
all tissue except the relatively impermeable blood–brain and inner retinal barriers) that …

Publisher Summary This chapter discusses the structure and function of the epidermal
growth factor (EGF) receptor (EGFR), from ligand binding to the initiation of intracellular …

The endothelium functions as a semipermeable barrier regulating tissue fluid homeostasis
and transmigration of leukocytes and providing essential nutrients across the vessel wall …

Considerable evidence now implicates elevated expression and/or activity of Src in cancer
development. In cells, endogenous Src is switched from an inactive to an active state by a …

Rho family small GTPases serve as molecular switches involved in the regulation of diverse
cellular functions including various cytoskeleton-related events and gene transcription. The …

The Rho GTPases are implicated in almost every fundamental cellular process. They act as
molecular switches that cycle between an active GTP‐bound and an inactive GDP‐bound …

Src family tyrosine kinases (SFKs) are involved in a diverse array of physiological
processes, as highlighted in this review. An overview of how SFKs interact with, and …

The binding of extracellular matrix proteins to integrins triggers rearrangements in the actin
cytoskeleton by regulating the Rho family of small GTPases. The signaling events that …

The ras genes give rise to a family of related GTP-binding proteins that exhibit potent
transforming potential. Mutational activation of Ras proteins promotes oncogenesis by …

The transforming gene of the Rous sarcoma virus, v-src, is a mutated and activated version
of a normal cellular gene, c-src, which encodes a protein with intrinsic tyrosine kinase …