Developing reliable, predictive animal models for complex psychiatric disorders, such as
schizophrenia, is essential to increase our understanding of the neurobiological basis of the …

An emerging literature from epidemiologic, clinical, and preclinical investigations has
provided evidence that gestational exposure to infection contributes to the etiology of …

Schizophrenia is a complex and multifactorial disorder generally diagnosed in young adults
at the time of the first psychotic episode of delusions and hallucinations. These positive …

Temporal lobe epilepsy is a common, chronic neurological disorder characterized by
recurrent spontaneous seizures. MicroRNAs (miRNAs) are small, noncoding RNAs that …

The epidermal growth factor receptor (EGFR) is the prototypical member of a family of
membrane-associated intrinsic tyrosine kinase receptors, the ErbB family. EGFR is activated …

Schizophrenia is a highly debilitating mental disorder that affects∼ 1% of the general
population, yet it continues to be poorly understood. Recent studies have identified …

We have used a translational convergent functional genomics (CFG) approach to identify
and prioritize genes involved in schizophrenia, by gene-level integration of genome-wide …

The mammalian amygdala is a key emotional brain region for eliciting social behaviour,
critically involved in anxiety and fear-related behaviours, and hence a focus of research on …

Over the last decade, there has been increased interest in the role of the gut microbiome in
health including brain health. This is by no means a new theory; Elie Metchnikoff proposed …

Neuregulin 1 (NRG1) is a trophic factor thought to play a role in neural development. Recent
studies suggest that it may regulate neurotransmission, mechanisms of which remain …