The biofilm life cycle: expanding the conceptual model of biofilm formation

K Sauer, P Stoodley, DM Goeres… - Nature Reviews …, 2022 - nature.com
Bacterial biofilms are often defined as communities of surface-attached bacteria and are
typically depicted with a classic mushroom-shaped structure characteristic of Pseudomonas …

[HTML][HTML] Mimicking biofilm formation and development: Recent progress in in vitro and in vivo biofilm models

I Guzmán-Soto, C McTiernan, M Gonzalez-Gomez… - Iscience, 2021 - cell.com
Biofilm formation in living organisms is associated to tissue and implant infections, and it has
also been linked to the contribution of antibiotic resistance. Thus, understanding biofilm …

Molecular mechanisms of biofilm-based antibiotic resistance and tolerance in pathogenic bacteria

CW Hall, TF Mah - FEMS microbiology reviews, 2017 - academic.oup.com
Biofilms are surface-attached groups of microbial cells encased in an extracellular matrix
that are significantly less susceptible to antimicrobial agents than non-adherent, planktonic …

Strategies for combating bacterial biofilms: A focus on anti-biofilm agents and their mechanisms of action

R Roy, M Tiwari, G Donelli, V Tiwari - Virulence, 2018 - Taylor & Francis
Biofilm refers to the complex, sessile communities of microbes found either attached to a
surface or buried firmly in an extracellular matrix as aggregates. The biofilm matrix …

Biofilm formation and inhibition mediated by bacterial quorum sensing

Y Wang, Z Bian, Y Wang - Applied Microbiology and Biotechnology, 2022 - Springer
As a complex microbial aggregate, biofilm is a group behavior of bacterial ability to adapt to
the environment. Bacteria produce biofilm substrates that enhance their tolerance to stress …

Pseudomonas aeruginosa Biofilms: Host Response and Clinical Implications in Lung Infections

NM Maurice, B Bedi, RT Sadikot - American journal of respiratory …, 2018 - atsjournals.org
Pseudomonas aeruginosa is a major health challenge that causes recalcitrant multidrug-
resistant infections, especially in immunocompromised and hospitalized patients. P …

How microbes read the map: Effects of implant topography on bacterial adhesion and biofilm formation

SW Lee, KS Phillips, H Gu, M Kazemzadeh-Narbat… - Biomaterials, 2021 - Elsevier
Microbes have remarkable capabilities to attach to the surface of implanted medical devices
and form biofilms that adversely impact device function and increase the risk of multidrug …

[HTML][HTML] Pseudomonas aeruginosa aggregates in cystic fibrosis sputum produce exopolysaccharides that likely impede current therapies

LK Jennings, JE Dreifus, C Reichhardt, KM Storek… - Cell reports, 2021 - cell.com
In cystic fibrosis (CF) airways, Pseudomonas aeruginosa forms cellular aggregates called
biofilms that are thought to contribute to chronic infection. To form aggregates, P. aeruginosa …

[HTML][HTML] The non-attached biofilm aggregate

KN Kragh, T Tolker-Nielsen, M Lichtenberg - Communications Biology, 2023 - nature.com
Biofilms have conventionally been perceived as dense bacterial masses on surfaces,
following the five-step model of development. Initial biofilm research focused on surface …

The role of bacterial biofilms in chronic infections

T Bjarnsholt - Apmis, 2013 - Wiley Online Library
Acute infections caused by pathogenic bacteria have been studied extensively for well over
100 years. These infections killed millions of people in previous centuries, but they have …