Recovery from disorders of consciousness: mechanisms, prognosis and emerging therapies

BL Edlow, J Claassen, ND Schiff… - Nature Reviews Neurology, 2021 - nature.com
Substantial progress has been made over the past two decades in detecting, predicting and
promoting recovery of consciousness in patients with disorders of consciousness (DoC) …

[HTML][HTML] Conscious processing and the global neuronal workspace hypothesis

GA Mashour, P Roelfsema, JP Changeux, S Dehaene - Neuron, 2020 - cell.com
We review the central tenets and neuroanatomical basis of the global neuronal workspace
(GNW) hypothesis, which attempts to account for the main scientific observations regarding …

Sleep deprivation and neurological disorders

M Bishir, A Bhat, MM Essa, O Ekpo… - BioMed research …, 2020 - Wiley Online Library
Sleep plays an important role in maintaining neuronal circuitry, signalling and helps
maintain overall health and wellbeing. Sleep deprivation (SD) disturbs the circadian …

Deep brain stimulation of the thalamus restores signatures of consciousness in a nonhuman primate model

J Tasserie, L Uhrig, JD Sitt, D Manasova, M Dupont… - Science …, 2022 - science.org
Loss of consciousness is associated with the disruption of long-range thalamocortical and
corticocortical brain communication. We tested the hypothesis that deep brain stimulation …

Thalamic deep brain stimulation in traumatic brain injury: a phase 1, randomized feasibility study

ND Schiff, JT Giacino, CR Butson, EY Choi, JL Baker… - Nature medicine, 2023 - nature.com
Converging evidence indicates that impairments in executive function and information-
processing speed limit quality of life and social reentry after moderate-to-severe traumatic …

Cellular mechanisms of conscious processing

J Aru, M Suzuki, ME Larkum - Trends in cognitive sciences, 2020 - cell.com
Recent breakthroughs in neurobiology indicate that the time is ripe to understand how
cellular-level mechanisms are related to conscious experience. Here, we highlight the …

[HTML][HTML] Thalamus modulates consciousness via layer-specific control of cortex

MJ Redinbaugh, JM Phillips, NA Kambi, S Mohanta… - Neuron, 2020 - cell.com
Functional MRI and electrophysiology studies suggest that consciousness depends on large-
scale thalamocortical and corticocortical interactions. However, it is unclear how neurons in …

Neural correlates of consciousness: progress and problems

C Koch, M Massimini, M Boly, G Tononi - Nature reviews neuroscience, 2016 - nature.com
There have been a number of advances in the search for the neural correlates of
consciousness—the minimum neural mechanisms sufficient for any one specific conscious …

Therapeutic interventions in patients with prolonged disorders of consciousness

A Thibaut, N Schiff, J Giacino, S Laureys… - The Lancet …, 2019 - thelancet.com
The management of patients with severe brain injuries and prolonged disorders of
consciousness raises important issues particularly with respect to their therapeutic options …

Neural signs and mechanisms of consciousness: Is there a potential convergence of theories of consciousness in sight?

G Northoff, V Lamme - Neuroscience & Biobehavioral Reviews, 2020 - Elsevier
Various theories for the neural basis of consciousness have been proposed, suggesting a
diversity of neural signs and mechanisms. We ask to what extent this diversity is real, or …