The immune system of multicellular organisms protects them from harmful microbes. To
establish an infection in the face of host immune responses, pathogens must evolve specific …

Guanylate-binding proteins (GBPs) are a family of intracellular proteins which have diverse
biological functions, including pathogen sensing and host defense against infectious …

Pathogenic microbes invade the human body and trigger a host immune response to defend
against the infection. In response, host-adapted pathogens employ numerous virulence …

Cell-intrinsic defense is an essential part of the immune response against intracellular
pathogens regulated by cytokine-induced proteins and pathways. One of the most …

Shigella spp. cause hundreds of millions of intestinal infections each year. They target the
mucosa of the human colon and are an important model of intracellular bacterial …

Pyroptosis is a proinflammatory form of programmed cell death featured with membrane
pore formation that causes cellular swelling and allows the release of intracellular …

Pathogenesis of Pseudomonas aeruginosa infections can include bacterial survival inside
epithelial cells. Previously, we showed that this involves multiple roles played by the type …

The dynamin-related human guanylate-binding protein 1 (GBP1) mediates host defenses
against microbial pathogens. Upon GTP binding and hydrolysis, auto-inhibited GBP1 …

Mammalian innate immunity is regulated by pattern-recognition receptors (PRRs) and guard
proteins, which use distinct strategies to detect infections. PRRs detect bacterial molecules …

Our epithelium represents a battle ground against a variety of insults including pathogens
and danger signals. It encodes multiple sensors that detect and respond to such insults …