Physiological and molecular basis of thyroid hormone action
PM Yen - Physiological reviews, 2001 - journals.physiology.org
Thyroid hormones (THs) play critical roles in the differentiation, growth, metabolism, and
physiological function of virtually all tissues. TH binds to receptors that are ligand …
physiological function of virtually all tissues. TH binds to receptors that are ligand …
Thyroid hormone receptors in brain development and function
J Bernal - Nature clinical practice Endocrinology & metabolism, 2007 - nature.com
Thyroid hormones are important during development of the mammalian brain, acting on
migration and differentiation of neural cells, synaptogenesis, and myelination. The actions of …
migration and differentiation of neural cells, synaptogenesis, and myelination. The actions of …
Thyroid hormone receptors: multiple forms, multiple possibilities
MA Lazar - Endocrine reviews, 1993 - academic.oup.com
I. Introduction T HE biological importance of the thyroid gland has been recognized for
centuries (1). The realization in the late 19th century that cretinism and myxedema result …
centuries (1). The realization in the late 19th century that cretinism and myxedema result …
The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function
NL Chamberlain, ED Driver… - Nucleic acids research, 1994 - academic.oup.com
Some transcription factors contain stretches of polyglutamine encoded by repeats of the
trinucleotide CAG. Expansion of the CAG repeat in the androgen receptor (AR) has been …
trinucleotide CAG. Expansion of the CAG repeat in the androgen receptor (AR) has been …
Neurodevelopmental and neurophysiological actions of thyroid hormone
GR Williams - Journal of neuroendocrinology, 2008 - Wiley Online Library
For over 100 years, thyroid hormones have been known to be essential for neonatal
neurodevelopment but whether they are required by the foetal brain remains a matter of …
neurodevelopment but whether they are required by the foetal brain remains a matter of …
Psychological well‐being in patients on 'adequate' doses of l‐thyroxine: results of a large, controlled community‐based questionnaire study
P Saravanan, WF Chau, N Roberts… - Clinical …, 2002 - Wiley Online Library
Summary objective Over 1% of the UK population is receiving thyroid hormone replacement
with l‐thyroxine (T4). However, many patients complain of persistent lethargy and related …
with l‐thyroxine (T4). However, many patients complain of persistent lethargy and related …
Structure–function relationship of estrogen receptor α and β: Impact on human health
P Ascenzi, A Bocedi, M Marino - Molecular aspects of medicine, 2006 - Elsevier
17β-Estradiol (E2) controls many aspects of human physiology, including development,
reproduction and homeostasis, through regulation of the transcriptional activity of its cognate …
reproduction and homeostasis, through regulation of the transcriptional activity of its cognate …
A novel role for thyroid hormone, glucocorticoids and retinoic acid in timing oligodendrocyte development
The timing of oligodendrocyte differentiation is thought to depend on an intrinsic clock in
oligodendrocyte precursor cells that counts time or cell divisions and limits precursor cell …
oligodendrocyte precursor cells that counts time or cell divisions and limits precursor cell …
A thyroid hormone receptor that is required for the development of green cone photoreceptors
L Ng, JB Hurley, B Dierks, M Srinivas, C Saltó… - Nature …, 2001 - nature.com
Color vision is facilitated by distinct populations of cone photoreceptors in the retina. In
rodents, cones expressing different opsin photopigments are sensitive to middle (M,'green') …
rodents, cones expressing different opsin photopigments are sensitive to middle (M,'green') …
Estrogen receptor interaction with co-activators and co-repressors☆
CM Klinge - Steroids, 2000 - Elsevier
Estrogens exert a wide variety of effects on growth, development, and differentiation,
including important regulatory functions within the reproductive systems of both females and …
including important regulatory functions within the reproductive systems of both females and …