The chemokines (or chemotactic cytokines) are a large family of small, secreted proteins that
signal through cell surface G protein‐coupled heptahelical chemokine receptors. They are …

Dendritic cells (DC) are specialized immune cells that play a critical role in promoting an
immune response against Ags, which can include foreign pathogenic Ags and self-tumor …

Comprehensive analysis of the gene expression profiles associated with human monocyte-
to-macrophage differentiation and polarization toward M1 or M2 phenotypes led to the …

A key feature of the immune system is its ability to induce protective immunity against
pathogens while maintaining tolerance towards self and innocuous environmental antigens …

Dendritic cells (DCs) are professional antigen-presenting cells responsible for the activation
of specific T-cell responses and for the development of immune tolerance. Immature DCs …

The proper function of immune surveillance requires well-coordinated mechanisms in order
to guide the patrolling immune cells through peripheral tissues and into secondary lymphoid …

During the last five years, the development of bioinformatics and EST databases has been
primarily responsible for the identification of many new chemokines and chemokine …

Chemokine receptors comprise a large family of seven transmembrane domain G protein-
coupled receptors differentially expressed in diverse cell types. Biological activities have …

Dendritic cells (DCs) and macrophages are professional antigen-presenting cells (APCs)
that play key roles in both innate and adaptive immunity. ChemR23 is an orphan G protein …

Antigen-presenting dendritic cells often acquire foreign antigens in peripheral tissues such
as the skin. Optimal encounter with naive T cells for the presentation of these antigens …