Unicellular organisms respond to the presence of DNA lesions by activating cell cycle
checkpoint and repair mechanisms, while multicellular animals have acquired the further …

Programmed cell death (PCD) is involved in the removal of superfluous and damaged cells
in most organ systems. The induction phase of PCD or apoptosis is characterized by an …

Cyclin‐dependent kinases (cdk) play an essential role in the intracellular control of the cell
division cycle (cdc). These kinases and their regulators are frequently deregulated in human …

INTRODUCTION Cyclins are the activating partners of a highly conserved family of
proteinkinases, the cyclin-dependent kinases (CDKs). A number of diverse cyclins and …

The cyclin-dependent kinase 1 (Cdk1), formerly called Cdc2 (or p34 Cdc2), interacts with
cyclin B1 to form an active heterodimer. The activity of Cdk1 is subjected to a complex …

Programmed cell death, or apoptosis, is a highly regulated process used to eliminate
unwanted or damaged cells from multicellular organisms. The morphology of cells …

Specific proteinases of the Ced-3/interleukin-1β converting enzyme family trigger a multi-
enzyme cascade that drives apoptotic events. Studies with newly developed cell-free …

The human immunodeficiency virus type 1 (HIV-1) vpr gene encodes a protein which
induces arrest of cells in the G2 phase of the cell cycle. Here, we demonstrate that following …

The mechanism (s) leading to widespread hyper-phosphorylation of proteins in Alzheimer's
disease (AD) are unknown. We have characterized seven new monoclonal antibodies …

Apoptosis is an evolutionarily conserved 'suicide'programme present in all metazoan cells.
Despite its highly conserved nature, it is only recently that any of the molecular mechanisms …