Mapping human brain lesions and their functional consequences
HO Karnath, C Sperber, C Rorden - Neuroimage, 2018 - Elsevier
Neuroscience has a long history of inferring brain function by examining the relationship
between brain injury and subsequent behavioral impairments. The primary advantage of this …
between brain injury and subsequent behavioral impairments. The primary advantage of this …
Embracing variability in the search for biological mechanisms of psychiatric illness
Despite decades of research, we lack objective diagnostic or prognostic biomarkers of
mental health problems. A key reason for this limited progress is a reliance on the traditional …
mental health problems. A key reason for this limited progress is a reliance on the traditional …
Advanced lesion symptom mapping analyses and implementation as BCBtoolkit
Background Patients with brain lesions provide a unique opportunity to understand the
functioning of the human mind. However, even when focal, brain lesions have local and …
functioning of the human mind. However, even when focal, brain lesions have local and …
Common genetic variation influencing human white matter microstructure
INTRODUCTION White matter in the human brain serves a critical role in organizing
distributed neural networks. Diffusion magnetic resonance imaging (dMRI) has enabled the …
distributed neural networks. Diffusion magnetic resonance imaging (dMRI) has enabled the …
Structural disconnections explain brain network dysfunction after stroke
Stroke causes focal brain lesions that disrupt functional connectivity (FC), a measure of
activity synchronization, throughout distributed brain networks. It is often assumed that FC …
activity synchronization, throughout distributed brain networks. It is often assumed that FC …
Network diffusion model of progression predicts longitudinal patterns of atrophy and metabolism in Alzheimer's disease
A Raj, E LoCastro, A Kuceyeski, D Tosun, N Relkin… - Cell reports, 2015 - cell.com
Alzheimer's disease pathology (AD) originates in the hippocampus and subsequently
spreads to temporal, parietal, and prefrontal association cortices in a relatively stereotyped …
spreads to temporal, parietal, and prefrontal association cortices in a relatively stereotyped …
Regional, circuit and network heterogeneity of brain abnormalities in psychiatric disorders
The substantial individual heterogeneity that characterizes people with mental illness is
often ignored by classical case–control research, which relies on group mean comparisons …
often ignored by classical case–control research, which relies on group mean comparisons …
[HTML][HTML] Lesion Quantification Toolkit: A MATLAB software tool for estimating grey matter damage and white matter disconnections in patients with focal brain lesions
Lesion studies are an important tool for cognitive neuroscientists and neurologists. However,
while brain lesion studies have traditionally aimed to localize neurological symptoms to …
while brain lesion studies have traditionally aimed to localize neurological symptoms to …
[HTML][HTML] The impact of epilepsy surgery on the structural connectome and its relation to outcome
Background Temporal lobe surgical resection brings seizure remission in up to 80% of
patients, with long-term complete seizure freedom in 41%. However, it is unclear how …
patients, with long-term complete seizure freedom in 41%. However, it is unclear how …
[HTML][HTML] Functional connectome reorganization relates to post-stroke motor recovery and structural and functional disconnection
Motor recovery following ischemic stroke is contingent on the ability of surviving brain
networks to compensate for damaged tissue. In rodent models, sensory and motor cortical …
networks to compensate for damaged tissue. In rodent models, sensory and motor cortical …