Abstract Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) is a severe
reaction to drugs. Incidence of DRESS in children is not well known and the mortality rate …

Phenobarbital is an effective and safe anticonvulsant drug introduced in clinical use in 1904.
Its mechanism of action is the synaptic inhibition through an action on GABAA. The loading …

Background Phenytoin is one of the most common causative drugs of several types of
severe cutaneous adverse reactions (SCAR) such as Stevens–Johnson syndrome (SJS) …

The presence of phenobarbital and formaldehyde in drugs, food, and beverages can lead to
various health issues, including inflammation, oncogenesis, and neurological distress …

Selecting the most appropriate antiepileptic drug (AED) or combination of drugs for each
patient and identifying the most suitable therapeutic regimen for their needs is increasingly …

Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are immunologic
reactions to several stimuli, mostly medications, which present as a spectrum of primarily …

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are adverse
reactions that affect the mucocutaneous surfaces by causing necrosis and detachment of the …

Epilepsy affects approximately 10 million children globally. Antiepileptic drugs (AEDs) are
among the most frequent causes of drug hypersensitivity reactions (DHRs), especially …

Background Severe cutaneous adverse reactions (SCARs) are delayed‐type
hypersensitivity reactions to drugs including as follows: Drug Reaction with Eosinophilia and …

Antiepileptic drugs can induce potentially life-threatening hypersensitivity reactions such as
Stevens–Johnson syndrome at a frequency of one in 10,000 to one in 1000 treated patients …