The present report focuses on the various aspects of oral delivery of anticancer drugs. The
significance of oral delivery in cancer therapeutics has been highlighted which principally …

Supported by detailed understanding of their mechanism of action, and facilitated by
chemical manipulations that have amplified their solubility, the camptothecins have …

PURPOSE Single-agent chemotherapies have limited activity and considerable toxicity in
patients with platinum-resistant epithelial ovarian cancer (PROC). Mirvetuximab …

Purpose Ovarian cancer (OC) patients experiencing progressive disease (PD) within 6
months of platinum-based therapy in the primary setting are considered platinum resistant …

Purpose Single-agent intravenous (IV) topotecan is an effective treatment for small-cell lung
cancer (SCLC) after failure of first-line chemotherapy. This open-label, randomized, phase III …

Objective The randomized phase 3 CORAIL trial evaluated whether lurbinectedin improved
progression-free survival (PFS) compared to pegylated liposomal doxorubicin (PLD) or …

Simple Summary In this retrospective analysis of 72 advanced ovarian cancer patients, we
have evaluated the safety and activity of orally-administered metronomic chemotherapy …

For women with advanced ovarian cancer, rates of response to first-line chemotherapy are
high but most patients have relapses and become candidates for further chemotherapy …

Abstract Purpose: A Phase I/IIb multicenter study was conducted to evaluate the safety and
immunogenicity of the anti-idiotypic antibody vaccine ACA125 that functionally imitates the …

Camptothecins represent an established class of effective agents that selectively target
topoisomerase I by trapping the catalytic intermediate of the topoisomerase I-DNA reaction …