Cells use messenger RNAs (mRNAs) to ensure the accurate dissemination of genetic
information encoded by DNA. Given that mRNAs largely direct the synthesis of a critical …

IN THE LATE 1980s and early 1990s, the elucidation of the molecular basis of acute
promyelocytic leukemia (APL) emerged as a paradigm for the connection between the …

The epidemiology and molecular biology of colorectal cancer are reviewed with a view to
understanding their interrelationship. Risk factors for colorectal neoplasia include a positive …

The PML protein is associated to nuclear bodies (NBs) whose functions are as yet unknown.
PML and two other NBs-associated proteins, Sp100 And ISG20 are directly induced by …

The 9ORF1 gene encodes an adenovirus E4 region oncoprotein that requires a C-terminal
region for transforming activity. Screening a λgt11 cDNA expression library with a 9ORF1 …

The promyelocytic leukemia (PML) nuclear body (also referred to as ND10, POD, and Kr
body) is involved in oncogenesis and viral infection. This subnuclear domain has been …

Interferons (IFNs) are a family of secreted proteins with antiviral, antiproliferative and
immunomodulatory activities. The different biological actions of IFN are believed to be …

ABSTRACT PML nuclear bodies (NBs) are subnuclear structures whose integrity is
compromised in certain human diseases, including leukemia and neurodegenerative …

The Tax1 oncoprotein encoded by Human T-lymphotropic virus type I is a major determinant
of viral persistence and pathogenesis. Tax1 affects a wide variety of cellular signalling …

PML and Sp100 proteins are associated with nuclear domains, known as nuclear dots
(NDs). They were discovered in the context of leukemic transformation and as an …