From therapeutic drug monitoring to model‐informed precision dosing for antibiotics

SG Wicha, AG Märtson, EI Nielsen… - Clinical …, 2021 - Wiley Online Library
Therapeutic drug monitoring (TDM) and model‐informed precision dosing (MIPD) have
evolved as important tools to inform rational dosing of antibiotics in individual patients with …

Saliva sampling: Methods and devices. An overview

FG Bellagambi, T Lomonaco, P Salvo, F Vivaldi… - TrAC Trends in …, 2020 - Elsevier
The continuous exchange of chemicals with blood and the non-invasive collection make
saliva an interesting specimen for clinical applications, from the detection of biomarkers to …

Toward SERS-based therapeutic drug monitoring in clinical settings: Recent developments and trends

C Liu, S Weber, R Peng, L Wu, W Zhang… - TrAC Trends in …, 2023 - Elsevier
Therapeutic drug monitoring (TDM) plays an important role in ensuring optimal drug therapy
and has become increasingly important in clinical practice. In the first part of this review …

[HTML][HTML] Model-informed precision dosing: State of the art and future perspectives

IK Minichmayr, E Dreesen, M Centanni, Z Wang… - Advanced drug delivery …, 2024 - Elsevier
Abstract Model-informed precision dosing (MIPD) stands as a significant development in
personalized medicine to tailor drug dosing to individual patient characteristics. MIPD moves …

Integrating pharmacokinetics and pharmacodynamics in operational research to end tuberculosis

JWC Alffenaar, T Gumbo, KE Dooley… - Clinical Infectious …, 2020 - academic.oup.com
Tuberculosis (TB) elimination requires innovative approaches. The new Global Tuberculosis
Network (GTN) aims to conduct research on key unmet therapeutic and diagnostic needs in …

Wireless, noninvasive therapeutic drug monitoring system for saliva measurement toward medication management of schizophrenia

Z Yan, Z Shi, Y Wu, J Lv, P Deng, G Liu, Z An… - Biosensors and …, 2023 - Elsevier
As an efficient patient management tool of precision medicine, decentralized therapeutic
drug monitoring (TDM) provides new vision for therapy adherence and health management …

Alternative methods for therapeutic drug monitoring and dose adjustment of tuberculosis treatment in clinical settings: a systematic review

PS Rao, N Modi, NTT Nguyen, DH Vu, YL Xie… - Clinical …, 2023 - Springer
Abstract Background and Objective Quantifying exposure to drugs for personalized dose
adjustment is of critical importance in patients with tuberculosis who may be at risk of …

A mobile microvolume UV/visible light spectrophotometer for the measurement of levofloxacin in saliva

JWC Alffenaar, EM Jongedijk… - Journal of …, 2021 - academic.oup.com
Introduction Therapeutic drug monitoring (TDM) for personalized dosing of fluoroquinolones
has been recommended to optimize efficacy and reduce acquired drug resistance in the …

Evaluation of saliva as a potential alternative sampling matrix for therapeutic drug monitoring of levofloxacin in patients with multidrug-resistant tuberculosis

S Ghimire, B Maharjan, EM Jongedijk… - Antimicrobial Agents …, 2019 - Am Soc Microbiol
Saliva may be a useful alternative matrix for monitoring levofloxacin concentrations in
multidrug-resistant tuberculosis (MDR-TB) patients. The objectives of this study were (i) to …

Semi-automated therapeutic drug monitoring as a pillar toward personalized medicine for tuberculosis management

RP Jayanti, NP Long, NK Phat, YS Cho, JG Shin - Pharmaceutics, 2022 - mdpi.com
Standard tuberculosis (TB) management has failed to control the growing number of drug-
resistant TB cases worldwide. Therefore, innovative approaches are required to eradicate …