Molecular and functional neuroscience in immunity
The nervous system regulates immunity and inflammation. The molecular detection of
pathogen fragments, cytokines, and other immune molecules by sensory neurons generates …
pathogen fragments, cytokines, and other immune molecules by sensory neurons generates …
Autoantibodies in systemic lupus erythematosus: From immunopathology to therapeutic target
H Lou, GS Ling, X Cao - Journal of autoimmunity, 2022 - Elsevier
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple
organ inflammatory damage and wide spectrum of autoantibodies. The autoantibodies …
organ inflammatory damage and wide spectrum of autoantibodies. The autoantibodies …
[HTML][HTML] Systemic inflammation and the brain: novel roles of genetic, molecular, and environmental cues as drivers of neurodegeneration
R Sankowski, S Mader… - Frontiers in cellular …, 2015 - frontiersin.org
The nervous and immune systems have evolved in parallel from the early bilaterians, in
which innate immunity and a central nervous system (CNS) coexisted for the first time, to …
which innate immunity and a central nervous system (CNS) coexisted for the first time, to …
Taming lupus—a new understanding of pathogenesis is leading to clinical advances
Z Liu, A Davidson - Nature medicine, 2012 - nature.com
Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by the
loss of tolerance to nuclear self antigens, the production of pathogenic autoantibodies and …
loss of tolerance to nuclear self antigens, the production of pathogenic autoantibodies and …
Brain-reactive antibodies and disease
B Diamond, G Honig, S Mader… - Annual review of …, 2013 - annualreviews.org
Autoimmune diseases currently affect 5–7% of the world's population; in most diseases
there are circulating autoantibodies. Brain-reactive antibodies are present in approximately …
there are circulating autoantibodies. Brain-reactive antibodies are present in approximately …
[HTML][HTML] Towards drug repositioning: a unified computational framework for integrating multiple aspects of drug similarity and disease similarity
In response to the high cost and high risk associated with traditional de novo drug discovery,
investigation of potential additional uses for existing drugs, also known as drug …
investigation of potential additional uses for existing drugs, also known as drug …
Peptides and peptidomimetics as immunomodulators
AS Gokhale, S Satyanarayanajois - Immunotherapy, 2014 - Taylor & Francis
Peptides and peptidomimetics can function as immunomodulating agents by either blocking
the immune response or stimulating the immune response to generate tolerance …
the immune response or stimulating the immune response to generate tolerance …
[HTML][HTML] The therapeutic strategies for SLE by targeting anti-dsDNA antibodies
Y Wang, S Xiao, Y Xia, H Wang - Clinical reviews in allergy & immunology, 2022 - Springer
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by
diverse serological autoantibodies. Anti-dsDNA antibodies are involved in multiple organ …
diverse serological autoantibodies. Anti-dsDNA antibodies are involved in multiple organ …
Maternal anti-fetal brain IgG autoantibodies and autism spectrum disorder: current knowledge and its implications for potential therapeutics
E Fox-Edmiston, J Van de Water - CNS drugs, 2015 - Springer
Several studies have found a correlation between the presence of circulating maternal
autoantibodies and neuronal dysfunction in the neonate. Specifically, maternal anti-brain …
autoantibodies and neuronal dysfunction in the neonate. Specifically, maternal anti-brain …
Antibodies as mediators of brain pathology
The brain is normally sequestered from antibody exposure by the blood brain barrier.
However, antibodies can access the brain during fetal development before the barrier …
However, antibodies can access the brain during fetal development before the barrier …