Infections arising from multidrug-resistant pathogenic bacteria are spreading rapidly
throughout the world and threaten to become untreatable. The origins of resistance are …

Gene expression occurs in two essential steps: transcription and translation. In bacteria, the
two processes are tightly coupled in time and space, and highly regulated. Tight regulation …

Bacteriophages (phages) are critical players in the dynamics and function of microbial
communities and drive processes as diverse as global biogeochemical cycles and human …

OmpK35 and OmpK36 are the major outer membrane porins of Klebsiella pneumoniae. In
this study, a virulent clinical isolate was selected to study the role of these two porins in …

The development of antibiotic resistance is usually associated with genetic changes, either
to the acquisition of resistance genes, or to mutations in elements relevant for the activity of …

Background Glycerol has enhanced its biotechnological importance since it is a byproduct of
biodiesel synthesis. A study of Escherichia coli physiology during growth on glycerol was …

Phagocytosis is a pivotal process by which macrophages eliminate microorganisms after
recognition by pathogen sensors. Here we unexpectedly found that the self ligand and cell …

Despite the importance of maintaining redox homeostasis for cellular viability, how cells
control redox balance globally is poorly understood. Here we provide new mechanistic …

Streptomyces coelicolor GlnR is a global regulator that controls genes involved in nitrogen
metabolism. By genomic screening 10 new GlnR targets were identified, including enzymes …

Bacteria have a great capacity for adjusting their metabolism in response to environmental
changes by linking extracellular stimuli to the regulation of genes by transcription factors. By …