Bone sarcomas are a collection of sporadic malignancies of mesenchymal origin. The most
common subtypes include osteosarcoma, Ewing sarcoma, chondrosarcoma, and chordoma …

Mutations in subunits of the SWItch Sucrose Non-Fermentable (SWI/SNF) complex occur in
20% of all human tumors. Among these, the core subunit SMARCB1 is the most frequently …

Here, we show that tumor ADORA1 deletion suppresses cell growth in human melanoma
cell lines in vitro and tumor development in vivo in immune-deficient xenografts. However …

Selection of cancer patients for treatment with immune checkpoint inhibitors remains a
challenge due to tumour heterogeneity and variable biomarker detection. PD-L1 expression …

Background Chimeric antigen receptor (CAR) T cells and immune checkpoint blockades
(ICBs) have made remarkable breakthroughs in cancer treatment, but the efficacy is still …

Skull base chordoma (SBC) is a bone cancer with a high recurrence rate, high
radioresistance rate, and poorly understood mechanism. Here, we profiled the …

In this study, we investigated the clinical relevance of CD274 (PD-L1) protein expression by
tumor cells and tumor-infiltrating immune cells in colorectal cancer (CRC). To this end, 186 …

Simple Summary Chordomas and chondrosarcomas are rare tumors that can occur within
the skull base and spinal column and are often resistant to chemotherapy and radiation …

Neuroblastoma is the most common pediatric solid tumor of neural crest origin. The current
treatment options for neuroblastoma produce severe side effects. Programmed death-ligand …

Programmed death-ligand 1 (PD-L1) is a promising target of cancer immune therapy. It not
only expressed in tumor cells (TCs) but also up regulated in tumor infiltrating immune cells …