The passive stiffness of cardiac muscle plays a critical role in ventricular filling during
diastole and is determined by the extracellular matrix and the sarcomeric protein titin. Titin …

This review uses the giant muscle protein titin as an example to showcase the capability of
molecular dynamics simulations. Titin is responsible for the passive elasticity in muscle and …

Tip link filaments convey force and gate inner-ear hair-cell transduction channels to mediate
perception of sound and head movements. Cadherin-23 and protocadherin-15 form tip links …

Polyproteins, individual protein units joined covalently in tandem, have evolved as a
promising tool for measuring the dynamic folding of biomacromolecules in single-molecule …

While molecular dynamics (MD) simulations are routinely used to interpret atomic force
microscopy (AFM) experiments of protein unfolding, computational cost in MD simulations …

The thick filament-associated A-band region of titin is a highly repetitive component of the
titin chain with important scaffolding properties that support thick filament assembly. It also …

Titin is a large intrasarcomeric protein that, among its many roles in muscle, is thought to
modulate the in vivo assembly of the myosin motor filament. This is achieved through the …

Titin is a gigantic filamentous protein of the muscle sarcomere that plays roles in myofibril
mechanics and homoeostasis. 3D-structures of multi-domain fragments of titin are now …

Titin-like kinases are an important class of cytoskeletal kinases that intervene in the
response of muscle to mechanical stimulation, being central to myofibril homeostasis and …

Enterohemorrhagic and enteropathogenic Escherichia coli are among the most important
food-borne pathogens, posing a global health threat. The virulence factor intimin is essential …