In 2009, it was postulated that endothelial cells (ECs) would only be able to execute the
orders of growth factors if these cells would accordingly adapt their metabolism. Ten years …

Astrocytes outnumber neurons in the human brain, and they play a key role in numerous
functions within the central nervous system (CNS), including glutamate, ion (ie, Ca2+, K+) …

Mitochondria are the cells' powerhouse, but also their suicidal weapon store. Dozens of
lethal signal transduction pathways converge on mitochondria to cause the permeabilization …

Phenotypic and functional heterogeneity is one of the most relevant features of cancer cells
within different tumor types and is responsible for treatment failure. Cancer stem cells …

Redox-dependent processes influence most cellular functions, such as differentiation,
proliferation, and apoptosis. Mitochondria are at the center of these processes, as …

Angiogenesis has traditionally been viewed from the perspective of how endothelial cells
(ECs) coordinate migration and proliferation in response to growth factor activation to form …

Endothelial cells (ECs) are quiescent for years but can plastically switch to angiogenesis.
Vascular sprouting relies on the coordinated activity of migrating tip cells at the forefront and …

Blood vessels form an important interface between the environment and the organism by
carrying oxygen and nutrients to all cells and thus determining cellular metabolism. It is …

Cell function relies on the constant supply of ATP and it is crucial that mitochondrial ATP
production adapts to environmental and cellular challenges to maintain cellular function …

Cancer stem cells (CSCs) are a sub-population of tumour cells, which are responsible to
drive tumour growth, metastasis and therapy resistance. It has recently been proposed that …