Passing of Nanocarriers across the Histohematic Barriers: Current Approaches for Tumor Theranostics
K Gareev, R Tagaeva, D Bobkov, N Yudintceva… - Nanomaterials, 2023 - mdpi.com
Over the past several decades, nanocarriers have demonstrated diagnostic and therapeutic
(ie, theranostic) potencies in translational oncology, and some agents have been further …
(ie, theranostic) potencies in translational oncology, and some agents have been further …
Development of probes for radiotheranostics with albumin binding moiety to increase the therapeutic effects of astatine-211 (211At)
H Echigo, K Mishiro, M Munekane, T Fuchigami… - European Journal of …, 2024 - Springer
Purpose We have developed probes for multiradionuclides radiotheranostics using RGD
peptide ([67Ga] Ga-DOTA-c [RGDf (4-I) K]([67Ga] 1) and Ga-DOTA-[211At] c [RGDf (4-At) …
peptide ([67Ga] Ga-DOTA-c [RGDf (4-I) K]([67Ga] 1) and Ga-DOTA-[211At] c [RGDf (4-At) …
RGD peptide-conjugated dodecaborate with the Ga-DOTA complex: a preliminary study for the development of theranostic agents for boron neutron capture therapy …
A boron neutron capture therapy (BNCT) system, using boron-10-introduced agents coupled
with companion diagnostics, is anticipated as a promising cancer theranostic. Thus, this …
with companion diagnostics, is anticipated as a promising cancer theranostic. Thus, this …
Alpha Particle–Emitting Radiopharmaceuticals as Cancer Therapy: Biological Basis, Current Status, and Future Outlook for Therapeutics Discovery
RP Coll, SJ Bright, DKJ Martinus, DK Georgiou… - Molecular Imaging and …, 2023 - Springer
Critical advances in radionuclide therapy have led to encouraging new options for cancer
treatment through the pairing of clinically useful radiation-emitting radionuclides and …
treatment through the pairing of clinically useful radiation-emitting radionuclides and …
Therapeutic efficacy of 211 At-radiolabeled 2, 6-diisopropylphenyl azide in mouse models of human lung cancer
Targeted α-particle therapy (TAT) is an attractive alternative to conventional therapy for
cancer treatment. Among the available radionuclides considered for TAT, astatine-211 …
cancer treatment. Among the available radionuclides considered for TAT, astatine-211 …
Astatine-211-labeled aza-vesamicol derivatives as sigma receptor ligands for targeted alpha therapy
K Ogawa, K Nishizawa, K Washiyama… - Nuclear Medicine and …, 2023 - Elsevier
Introduction As sigma receptors are abundantly expressed on different types of cancer cells,
several radiolabeled sigma receptor ligands have been developed for cancer imaging and …
several radiolabeled sigma receptor ligands have been developed for cancer imaging and …
Development and evaluation of a theranostic probe with RGD peptide introduced platinum complex to enable tumor-specific accumulation
H Echigo, K Mishiro, M Munekane, T Fuchigami… - Bioorganic & Medicinal …, 2022 - Elsevier
Cisplatin (CDDP) has been widely used for chemotherapy. However, it has several
unfavorable side effects due to its low tumor selectivity. In this study, we designed …
unfavorable side effects due to its low tumor selectivity. In this study, we designed …
Optimizing the pharmacokinetics of an 211At-labeled RGD peptide with an albumin-binding moiety via the administration of an albumin-binding inhibitor
H Echigo, M Munekane, T Fuchigami… - European Journal of …, 2024 - Springer
Purpose A probe for targeted alpha therapy (TAT) using the RGD peptide (Ga-DOTA-K
([211At] APBA)-c (RGDfK)([211At] 1)) with albumin-binding moiety (ABM) was recently …
([211At] APBA)-c (RGDfK)([211At] 1)) with albumin-binding moiety (ABM) was recently …
Synthesis of closo-and nido-carborane derivatives of the KRGD peptide
DA Gruzdev, AV Vakhrushev, AM Demin… - Journal of …, 2024 - Elsevier
Peptides of the RGD family are of significant interest as vectors for targeted delivery of
various therapeutic and diagnostic groups to tumor cells. Their application can be especially …
various therapeutic and diagnostic groups to tumor cells. Their application can be especially …
Synthesis and evaluation of a deltic guanidinium analogue of a cyclic RGD peptide
K Mishiro, T Ueno, H Wakabayashi, M Fukui… - Organic & …, 2023 - pubs.rsc.org
A guanidine group is abundantly found in natural products and drugs. Guanidine has the
highest basicity among many common functional groups in nature. Because of its high …
highest basicity among many common functional groups in nature. Because of its high …