DNA methylation (5-methylcytosine, 5mC) is a major form of DNA modification in the
mammalian genome that plays critical roles in chromatin structure and gene expression. In …

DNA methylation has a profound impact on genome stability, transcription and development.
Although enzymes that catalyse DNA methylation have been well characterized, those that …

Methylation of cytosines in the mammalian genome represents a key epigenetic modification
and is dynamically regulated during development. Compelling evidence now suggests that …

Carcinogenesis involves uncontrolled cell growth, which follows the activation of oncogenes
and/or the deactivation of tumor suppression genes. Metastasis requires down-regulation of …

The ten–eleven translocation (TET) family of dioxygenases consists of three members,
TET1, TET2, and TET3. All three TET enzymes have Fe+ 2 and α-ketoglutarate (α-KG) …

The ten-eleven translocation (Tet) family of methylcytosine dioxygenases catalyze oxidation
of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and promote DNA …

Induced pluripotency is a powerful tool to derive patient-specific stem cells. In addition, it
provides a unique assay to study the interplay between transcription factors and chromatin …

Genome-wide erasure of DNA methylation takes place in primordial germ cells (PGCs) and
early embryos and is linked with pluripotency. Inhibition of Erk1/2 and Gsk3β signaling in …

Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3,
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …

Tet-mediated DNA oxidation is a recently identified mammalian epigenetic modification, and
its functional role in cell-fate transitions remains poorly understood. Here, we derive mouse …