Incretin hormones are gut peptides that are secreted after nutrient intake and stimulate
insulin secretion together with hyperglycaemia. GIP (glucose‐dependent insulinotropic …

In the last two decades we have witnessed sizable progress in defining the role of
gastrointestinal signals in the control of glucose and energy homeostasis. Specifically, the …

Diabetes is a disease characterized by a relative or absolute lack of insulin, leading to
hyperglycaemia. There are two main types of diabetes: type 1 diabetes and type 2 diabetes …

Insulin resistance in muscle and liver and-cell failure represent the core pathophysiologic
defects in type 2 diabetes. It now is recognized that the-cell failure occurs much earlier and …

Background Unlike most antihyperglycaemic drugs, glucagon-like peptide-1 (GLP-1)
receptor agonists have a glucose-dependent action and promote weight loss. We compared …

Gut peptides, exemplified by glucagon-like peptide-1 (GLP-1) and glucose-dependent
insulinotropic polypeptide (GIP) are secreted in a nutrient-dependent manner and stimulate …

Incretins are gut hormones that are secreted from enteroendocrine cells into the blood within
minutes after eating. One of their many physiological roles is to regulate the amount of …

Controversy exists regarding the potential regenerative influences of incretin therapy on
pancreatic β-cells versus possible adverse pancreatic proliferative effects. Examination of …

Diabetes mellitus has been recognized since antiquity. It currently affects as many as 285
million people worldwide and results in heavy personal and national economic burdens …

Introduction: Additional oral antidiabetic agents to metformin, sulfonylureas (SU) and
thiazolidinediones (TZD) are approved for the treatment of type 2 diabetes. Areas covered …