CNS disorders are on the rise despite advancements in our understanding of their
pathophysiological mechanisms. A major hurdle to the treatment of these disorders is the …

Glioblastoma (GBM) is the most common aggressive malignant tumor in brain
neuroepithelial tumors and remains incurable. A variety of treatment options are currently …

The blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSF) are two of
the most complex and sophisticated concierges that defend the central nervous system …

Glioblastoma is the most frequent and malignant brain tumor. The median survival for this
disease is approximately 15 months, and despite all the available treatment strategies …

Systemic delivery of antiangiogenic agents has been ineffective in improving the overall
survival of patients with both primary and recurrent glioblastoma, in part due to dose-limiting …

Nanoghosts (NGs) are nanovesicles reconstructed from the cytoplasmic membranes of
mesenchymal stem cells (MSCs). By retaining MSC membranes, the NGs retain the ability of …

Strategies for cancer protein vaccination largely aim to activate the cellular arm of the
immune system against cancer cells. This approach, however, is limited since protein …

Convection-enhanced delivery (CED) is a promising investigational strategy for
locoregionally administering therapeutic agents directly into the brain parenchyma to treat …