Covering: 2013 to June 2018 Heterologous expression of natural product biosynthetic
pathways is of increasing interest in microbial biotechnology, drug discovery and …

Engineering microbial cells to efficiently synthesize high-value-added natural products has
received increasing attention in recent years. In this review, we describe the pipeline to build …

INTRODUCTION The human microbiome has been correlated with several health and
disease conditions, but the molecular mechanisms underlying these correlations remain …

Covering: 2005 up to 2019 Natural products are of paramount importance in human
medicine. Not only are most antibacterial and anticancer drugs derived directly from or …

The cryptic secondary metabolite biosynthetic gene clusters (BGCs) far outnumber currently
known secondary metabolites. Heterologous production of secondary metabolite BGCs in …

Bacillus species act as plant growth‐promoting rhizobacteria (PGPR) that can produce a
large number of bioactive metabolites. Bacillaene, a linear polyketide/nonribosomal peptide …

Metabolic engineering efforts toward rewiring metabolism of cells to produce new
compounds often require the utilization of non-native enzymatic machinery that is capable of …

Specialized metabolites from bacteria are an important source of inspiration for drug
development. The genes required for the biosynthesis of such metabolites in bacteria are …

In Bacillus subtilis, large genomic deletions have been carried out for genome reduction,
antibiotic overproduction, and heterologous protein overexpression. In view of the eco …

While the nutrient limited fed-batch technology is the standard of the cultivation of
microorganisms and production of heterologous proteins in industry, despite its advantages …