This year is the tenth anniversary of the publication in this journal of a model suggesting the
existence of'tumour progenitor genes'. These genes are epigenetically disrupted at the …

Pluripotency is a state that exists transiently in the early embryo and, remarkably, can be
recapitulated in vitro by deriving embryonic stem cells or by reprogramming somatic cells to …

Pluripotency, the ability to generate any cell type of the body, is an evanescent attribute of
embryonic cells. Transitory pluripotent cells can be captured at different time points during …

Somatic cell reprogramming to a pluripotent state continues to challenge many of our
assumptions about cellular specification, and despite major efforts, we lack a complete …

In the mouse, naïve pluripotent stem cells (PSCs) are thought to represent the cell culture
equivalent of the late epiblast in the pre-implantation embryo, with which they share a …

Cell identity is a reflection of a cell type‐specific gene expression profile, and consequently,
cell type‐specific transcription factor networks are considered to be at the heart of a given …

Differentiating somatic cells are progressively restricted to specialized functions during
ontogeny, but they can be experimentally directed to form other cell types, including those …

Embryonic pluripotency can be recapitulated in vitro by a spectrum of pluripotent stem cell
states stabilized with different culture conditions. Their distinct spatiotemporal characteristics …

Somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs), which is a
highly heterogeneous process. Here we report the cell fate continuum during somatic cell …

The rise of systems biology has ushered a new paradigm: the view of the cell as a system
that processes environmental inputs to drive phenotypic outputs. Synthetic biology provides …