The human gut microbiome is a critical component of digestion, breaking down complex
carbohydrates, proteins, and to a lesser extent fats that reach the lower gastrointestinal tract …

Over the past century, Escherichia coli has become one of the best studied organisms on
earth. Features such as genetic tractability, favorable growth conditions, well characterized …

Biological production of chemicals often requires the use of cellular cofactors, such as
nicotinamide adenine dinucleotide phosphate (NADP+). These cofactors are expensive to …

Noncanonical redox cofactors are attractive low-cost alternatives to nicotinamide adenine
dinucleotide (phosphate)(NAD (P)+) in biotransformation. However, engineering enzymes to …

Bio-refinery approach using agricultural and industrial waste material as feedstock is
becoming a preferred area of interest in biotechnology in the current decades. The reasons …

Enzymes need to be efficient, robust, and highly specific for their effective use in commercial
bioproduction. These properties can be introduced using various enzyme engineering …

Methane is considered a next-generation feedstock, and methanotrophic cell-based
biorefinery is attractive for production of a variety of high-value compounds from methane. In …

The non-natural needs of industrial applications often require new or improved enzymes.
The structures and properties of enzymes are difficult to predict or design de novo. Instead …

Nature's two redox cofactors, nicotinamide adenine dinucleotide (NAD+) and nicotinamide
adenine dinucleotide phosphate (NADP+), are held at different reduction potentials, driving …

Microbial processes can produce a wide range of compounds; however, producing complex
and long chain hydrocarbons remains a challenge. Aldol condensation offers a direct route …