Abstract Background Auger electrons (AEs) are very low energy electrons that are emitted
by radionuclides that decay by electron capture (eg 111 In, 67 Ga, 99m Tc, 195m Pt, 125 I …

The nucleus is an essential organelle for the function of cells. It holds most of the genetic
material and plays a crucial role in the regulation of cell growth and proliferation. Since …

Purpose The prostate-specific membrane antigen (PSMA) has emerged as an interesting
target for radionuclide therapy of metastasized castration-resistant prostate cancer …

Radioimmunotherapy (RIT) aims to selectively deliver radionuclides emitting α-particles, β-
particles or Auger electrons to tumors by conjugation to monoclonal antibodies (mAbs) that …

Targeting of tumors with radionuclides for radiotherapeutic purposes is often limited by
inadequate delivery to lesions using currently available targeting vehicles (eg, monoclonal …

The last decade has seen rapid growth in the use of theranostic radionuclides for the
treatment and imaging of a wide range of cancers. Radionuclide therapy and imaging rely …

High levels of glucagon-like peptide-1 (GLP-1) receptor expression in human insulinomas
and gastrinomas provide an attractive target for imaging, therapy, and intraoperative tumor …

The cytotoxicity and tumor-targeting properties of the anti-HER2/neu monoclonal antibody
trastuzumab modified with peptides (CGYG PKKKRKV GG) harboring the nuclear …

The review presented here lays out the present state of the art in the field of radionuclide
therapies specifically targeted against the nucleus of cancer cells, focussing on the use of …

Purpose: The extreme radiotoxicity of Auger electrons and their exquisite capacity to
irradiate specific molecular sites has prompted scientists to extensively investigate their …