Epidermal keratinocytes undergo a unique form of terminal differentiation and programmed
cell death known as cornification. Cornification leads to the formation of the outermost skin …

A large proportion of the cytoplasm of vertebrate cells, normal or transformed, is represented
by components of the cytoskeleton, including actin-containing microfilaments, tubulin …

Historically, the term 'keratin'stood for all of the proteins extracted from skin modifications,
such as horns, claws and hooves. Subsequently, it was realized that this keratin is actually a …

In this paper we present keratin expression data that lend strong support to a model of
corneal epithelial maturation in which the stem cells are located in the limbus, the …

Owing to several recent developments, the cultivability of epidermal keratinocytes,
particularly those of the human, has been greatly improved. Under the conditions used …

Cells of the inner layers of the epidermis contain small keratins (46~ 56K), whereas the cells
of the outer layers contain large keratins (63-6710 in addition to small ones. The changes in …

We have established cell lines from six human squamous cell carcinomas (SCC) of the
epidermis and tongue, using culture methods previously developed for clonal growth and …

Five chemically distinct classes of intermediate filaments can be identified within higher
eukaryotic cells. Each class is characteristic of a particular cell type. These filaments may …

Combined hepatocellular‐cholangiocarcinoma is a rare form of primary liver cancer
showing features of both hepatocellular and biliary epithelial differentiation. In a review of 24 …

Previously we demonstrated that transgenic mice expressing mutant basal epidermal keratin
genes exhibited a phenotype resembling a group of autosomal dominant human skin …