Native mass spectrometry (MS) involves the analysis and characterization of
macromolecules, predominantly intact proteins and protein complexes, whereby as much as …

Single-cell profiling methods have had a profound impact on the understanding of cellular
heterogeneity. While genomes and transcriptomes can be explored at the single-cell level …

We demonstrate single-particle charge detection mass spectrometry on an Orbitrap for the
analysis of megadalton biomolecular assemblies. We establish that the signal amplitudes of …

Micro and nanoelectromechanical systems M/NEMS have been extensively investigated
and exploited in the past few decades for various applications and for probing fundamental …

Frequency stability is key to the performance of nanoresonators. This stability is thought to
reach a limit with the resonator's ability to resolve thermally induced vibrations. Although …

Measurement of the mass of particles in the mega-to gigadalton range is challenging with
conventional mass spectrometry. Although this mass range appears optimal for …

Nanomechanical sensors and quantum nanosensors are two rapidly developing
technologies that have diverse interdisciplinary applications in biological and chemical …

Charge detection mass spectrometry (CDMS) is a single molecule method where the mass
of each ion is directly determined from individual measurements of its mass-to-charge ratio …

Nanomechanical mass spectrometry has proven to be well suited for the analysis of high
mass species such as viruses. Still, the use of one-dimensional devices such as vibrating …

Here we review recent developments in mass spectrometry that have enabled its growing
contribution to the field of structural virology. Evidently, there is a strong renewed general …