In the noisy cellular environment, gene products are subject to inherent random fluctuations
in copy numbers over time. How cells ensure precision in the timing of key intracellular …

The timing of a cellular event often hides critical information on the process leading to the
event. Our ability to measure event times in single cells along with other quantities allow us …

Cell-to-cell variability in the timing of cell-fate changes can be advantageous for a
population of single-celled organisms growing in a fluctuating environment. We study timing …

Timing is essential for many cellular processes, from cellular responses to external stimuli to
the cell cycle and circadian clocks. Many of these processes are based on gene expression …

Transcription factors and their target promoters are central to synthetic biology. By arranging
these components into novel gene regulatory circuits, synthetic biologists have been able to …

Protein noise measurements are increasingly used to elucidate biophysical parameters.
Unfortunately noise analyses are often at odds with directly measured parameters. Here we …

The post-transcriptional regulation of a protein by multiple small RNA molecules has been
formulated as a stochastic process. An approximate solution of the master equation shows …

An important function of microRNAs in gene regulation is to repress the protein synthesis in
a multi-step process with implications in timing efficiency of the regulatory network. We …

Gene expression is inherently a noisy process which manifests as cell-to-cell variability in
time evolution of proteins. Consequently, events that trigger at critical threshold levels of …

The timing of diverse cellular processes is based on the instant when the concentration of
regulatory proteins crosses a critical threshold level. Hence, noise mechanisms inherent to …