Management of endothelial dysfunction in systemic sclerosis: current and developing strategies
DC Zanin-Silva, M Santana-Gonçalves… - Frontiers in …, 2021 - frontiersin.org
Systemic Sclerosis (SSc) is an autoimmune disease marked by dysregulation of the immune
system, tissue fibrosis and dysfunction of the vasculature. Vascular damage, remodeling and …
system, tissue fibrosis and dysfunction of the vasculature. Vascular damage, remodeling and …
Involvement of the myeloid cell compartment in fibrogenesis and systemic sclerosis
G Kania, M Rudnik, O Distler - Nature Reviews Rheumatology, 2019 - nature.com
Systemic sclerosis (SSc) is an autoimmune fibrotic disease of unknown aetiology that is
characterized by vascular changes in the skin and visceral organs. Autologous …
characterized by vascular changes in the skin and visceral organs. Autologous …
Immune rebound associates with a favorable clinical response to autologous HSCT in systemic sclerosis patients
To evaluate the immunological mechanisms associated with clinical outcomes after
autologous hematopoietic stem cell transplantation (AHSCT), focusing on regulatory T …
autologous hematopoietic stem cell transplantation (AHSCT), focusing on regulatory T …
Myeloablation followed by autologous stem cell transplantation normalises systemic sclerosis molecular signatures
Objective In the randomised scleroderma: Cyclophosphamide Or Transplantation (SCOT
trial)(NCT00114530), myeloablation, followed by haematopoietic stem cell transplantation …
trial)(NCT00114530), myeloablation, followed by haematopoietic stem cell transplantation …
Autologous hematopoietic stem cell transplantation for treatment of systemic sclerosis
N Del Papa, F Pignataro, E Zaccara… - Frontiers in …, 2018 - frontiersin.org
Systemic Sclerosis (SSc) is a complex autoimmune disease, characterized by high mortality
and morbidity. The heterogeneity in terms of extent, severity, and rate of progression of skin …
and morbidity. The heterogeneity in terms of extent, severity, and rate of progression of skin …
Long-term immune reconstitution and T cell repertoire analysis after autologous hematopoietic stem cell transplantation in systemic sclerosis patients
The determinants of clinical responses after autologous hematopoietic stem cell
transplantation (aHSCT) in systemic sclerosis (SSc) are still unraveled. We analyzed long …
transplantation (aHSCT) in systemic sclerosis (SSc) are still unraveled. We analyzed long …
Autologous hematopoietic stem cell transplantation modifies specific aspects of systemic sclerosis-related microvasculopathy
M Santana-Gonçalves, D Zanin-Silva… - Therapeutic …, 2022 - journals.sagepub.com
Objective: Autologous hematopoietic stem cell transplantation (AHSCT) is a therapeutic
option for patients with severe and progressive systemic sclerosis (SSc). Here, we aimed to …
option for patients with severe and progressive systemic sclerosis (SSc). Here, we aimed to …
Autologous stem-cell transplantation in systemic sclerosis-associated interstitial lung disease: early action in selected patients rather than escalation therapy for all
J Spierings, YH Chiu, M Voortman… - Therapeutic …, 2021 - journals.sagepub.com
Systemic sclerosis (SSc) is a rare rheumatic disease characterised by inflammation,
vasculopathy and fibrosis of skin and internal organs. A common complication and a leading …
vasculopathy and fibrosis of skin and internal organs. A common complication and a leading …
Generation of a novel CD30+ B cell subset producing GM-CSF and its possible link to the pathogenesis of systemic sclerosis
K Higashioka, Y Kikushige, M Ayano… - Clinical & …, 2020 - academic.oup.com
Systemic sclerosis (SSc) is a T helper type 2 (Th2)-associated autoimmune disease
characterized by vasculopathy and fibrosis. Efficacy of B cell depletion therapy underscores …
characterized by vasculopathy and fibrosis. Efficacy of B cell depletion therapy underscores …
Autologous hematopoietic stem cell transplantation promotes connective tissue remodeling in systemic sclerosis patients
DC Zanin-Silva, M Santana-Gonçalves… - Arthritis Research & …, 2022 - Springer
Background Autologous hematopoietic stem cell transplantation (AHSCT) treats patients
with severe and progressive systemic sclerosis (SSc). However, basic mechanisms …
with severe and progressive systemic sclerosis (SSc). However, basic mechanisms …