The mammary gland is a compound, branched tubuloalveolar structure and a major
characteristic of mammals. The mammary gland has evolved from epidermal apocrine …

The mammary gland is a highly dynamic organ that undergoes profound changes within its
epithelium during puberty and the reproductive cycle. These changes are fueled by …

Since their identification in 1994, cancer stem cells (CSCs) have been objects of intensive
study. Their properties and mechanisms of formation have become a major focus of current …

The mammary epithelium is highly responsive to local and systemic signals, which
orchestrate morphogenesis of the ductal tree during puberty and pregnancy. Based on …

Both solid tumours and leukaemias show considerable histological and functional
heterogeneity. It is widely accepted that genetic lesions have a major role in determining …

The Notch signalling pathway is evolutionarily conserved and is crucial for the development
and homeostasis of most tissues. Deregulated Notch signalling leads to various diseases …

How the behaviour of somatic stem cells (SCs) is influenced by mechanical signals remains
a black-box in cell biology. Here we show that YAP/TAZ regulation by cell shape and rigidity …

Antiangiogenic therapy has been thought to hold significant potential for the treatment of
cancer. However, the efficacy of such treatments, especially in breast cancer patients, has …

The small airways of the human lung undergo pathological changes in pulmonary disorders,
such as chronic obstructive pulmonary disease (COPD), asthma, bronchiolitis obliterans and …

We report that breast cancer cells that infiltrate the lungs support their own metastasis-
initiating ability by expressing tenascin C (TNC). We find that the expression of TNC, an …