Adenosine acts in parallel as a neuromodulator and as a homeostatic modulator in the
central nervous system. Its neuromodulatory role relies on a balanced activation of inhibitory …

Adenosine exerts two parallel modulatory roles in the CNS, acting as a homeostatic
modulator and also as a neuromodulator at the synaptic level. We will present evidence to …

The inhibitory adenosine A1 receptor (A1R) and excitatory A2A receptor (A2AR) are
predominantly expressed in the brain. Whereas the A2AR has been implicated in normal …

1. Excitatory synaptic transmission between pairs of monosynaptically coupled pyramidal
cells was examined in rat hippocampal slice cultures. Action potentials were elicited in …

This review covers recent developments in the cellular neurophysiology of retrograde
signaling in the mammalian central nervous system. Normally at a chemical synapse a …

Mutations of the parkin gene are the most frequent cause of early onset autosomal recessive
parkinsonism (EO-AR). Here we show that inactivation of the parkin gene in mice results in …

An increasing number of studies show that both inflammation and neural plasticity act as key
players in the vulnerability and recovery from psychiatric disorders and neurodegenerative …

Communication between nerve cells in the central nervous system (CNS) occurs at
synapses, which are specialized sites between the presynaptic nerve terminal and the …

Neuroactive steroids refer to steroids that are capable of regulating neuronal activities.
Neuroactive steroids, synthesized either de novo in the nervous tissue or in the peripheral …

Adenosine is a potent modulator of neuronal activity throughout the nervous system.
Previous evidence suggests that adenosine presynaptically inhibits synaptic transmission …