Immobilization using external or internal splints is a standard and effective procedure to treat
minor skeletal fractures. In the case of major skeletal defects caused by extreme trauma …

Elucidation of the periosteum and its regenerative potential has become a hot topic in
orthopedics. Yet few review articles address the unique features of periosteum-derived cells …

Bone regeneration relies on the activation of skeletal stem cells (SSCs) that still remain
poorly characterized. Here, we show that periosteum contains SSCs with high bone …

The Ilizarov method of bone lengthening, reconstruction and osteosynthesis has developed
immensely since its introduction by GA Ilizarov in the Soviet Union in the 1960s and in the …

Congenital pseudarthrosis of the tibia (CPT) is an uncommon disease with various clinical
presentations ranging from simple anterolateral tibial angulation to complete non-union with …

To compare the current treatments for congenital pseudarthrosis of tibia, a total of 33 studies
were reviewed. Vascularized fibular graft with external fixation or combined fixation had the …

Periosteum is indispensable in bone repair and is an important source of skeletal stem cells
(SSCs) for endogenous bone regeneration. However, there are only a few studies about …

Congenital pseudarthrosis of the tibia (CPT) is likely to be a primary periosteal disease and
secondary bone disease. The primary goal of treatment is to obtain union, correct the …

Congenital pseudarthrosis of the tibia (CPT) is a rare pathology, which is usually associated
with neurofibromatosis type I. The natural history of the disease is extremely unfavorable …

Abstract Summary of background data The skeletal system is affected in up to 60% of
patients with neurofibromatosis type 1. The most commonly observed entities are spinal …