Organization and function of the 3D genome
Understanding how chromatin is organized within the nucleus and how this 3D architecture
influences gene regulation, cell fate decisions and evolution are major questions in cell …
influences gene regulation, cell fate decisions and evolution are major questions in cell …
A TAD skeptic: is 3D genome topology conserved?
IE Eres, Y Gilad - Trends in Genetics, 2021 - cell.com
The notion that topologically associating domains (TADs) are highly conserved across
species is prevalent in the field of 3D genomics. However, what exactly is meant by 'highly …
species is prevalent in the field of 3D genomics. However, what exactly is meant by 'highly …
[HTML][HTML] Reconstruction of proto-vertebrate, proto-cyclostome and proto-gnathostome genomes provides new insights into early vertebrate evolution
Ancient polyploidization events have had a lasting impact on vertebrate genome structure,
organization and function. Some key questions regarding the number of ancient …
organization and function. Some key questions regarding the number of ancient …
Evolution of the ancestral mammalian karyotype and syntenic regions
Decrypting the rearrangements that drive mammalian chromosome evolution is critical to
understanding the molecular bases of speciation, adaptation, and disease susceptibility …
understanding the molecular bases of speciation, adaptation, and disease susceptibility …
[HTML][HTML] The little skate genome and the evolutionary emergence of wing-like fins
F Marlétaz, E de la Calle-Mustienes, RD Acemel… - Nature, 2023 - nature.com
Skates are cartilaginous fish whose body plan features enlarged wing-like pectoral fins,
enabling them to thrive in benthic environments,. However, the molecular underpinnings of …
enabling them to thrive in benthic environments,. However, the molecular underpinnings of …
[HTML][HTML] Chromosome evolution at the origin of the ancestral vertebrate genome
Background It has been proposed that more than 450 million years ago, two successive
whole genome duplications took place in a marine chordate lineage before leading to the …
whole genome duplications took place in a marine chordate lineage before leading to the …
[HTML][HTML] The 3D architecture of the pepper genome and its relationship to function and evolution
The organization of chromatin into self-interacting domains is universal among eukaryotic
genomes, though how and why they form varies considerably. Here we report a …
genomes, though how and why they form varies considerably. Here we report a …
3D organization of chicken genome demonstrates evolutionary conservation of topologically associated domains and highlights unique architecture of erythrocytes' …
V Fishman, N Battulin, M Nuriddinov… - Nucleic acids …, 2019 - academic.oup.com
How chromosomes are folded, spatially organized and regulated in three dimensions inside
the cell nucleus are among the longest standing questions in cell biology. Genome-wide …
the cell nucleus are among the longest standing questions in cell biology. Genome-wide …
Epigenetic maintenance of topological domains in the highly rearranged gibbon genome
NH Lazar, KA Nevonen, B O'Connell… - Genome …, 2018 - genome.cshlp.org
The relationship between evolutionary genome remodeling and the three-dimensional
structure of the genome remain largely unexplored. Here, we use the heavily rearranged …
structure of the genome remain largely unexplored. Here, we use the heavily rearranged …
[HTML][HTML] Vertebrate chromosome evolution
The study of chromosome evolution is undergoing a resurgence of interest owing to
advances in DNA sequencing technology that facilitate the production of chromosome-scale …
advances in DNA sequencing technology that facilitate the production of chromosome-scale …