Cyclic nucleotide-gated (CNG) channels are nonselective cation channels first identified in
retinal photoreceptors and olfactory sensory neurons (OSNs). They are opened by the direct …

The adenylyl cyclases are variously regulated by G protein subunits, a number of
serine/threonine and tyrosine protein kinases, and Ca2+. In some physiological situations …

The cone and cone–rod dystrophies form part of a heterogeneous group of retinal disorders
that are an important cause of visual impairment in children and adults. There have been …

▪ Abstract Cyclic nucleotide-gated (CNG) ion channels were first discovered in rod
photoreceptors, where they are responsible for the primary electrical signal of the …

Mammalian cyclic nucleotide-gated (CNG) channels play an essential role in the signal
transduction of the visual and olfactory sensory systems. Here we reveal the structural …

Cyclic nucleotide–gated (CNG) channels are key to the signal transduction machinery of
certain sensory modalities both in vertebrate and invertebrate organisms. They translate a …

purpose. To determine the molecular basis for phenotypic variability in a three-generation
consanguineous family containing a single individual with complete achromatopsia and …

Few proteins have been described functionally in such detail as ion channels. All ion
channels open and close their ion-conducting pores, a process referred to as gating. The …

Mutations in the genes encoding the CNGA3 and CNGB3 subunits of the cyclic nucleotide-
gated (CNG) channel of cone photoreceptors have been associated with autosomal …

By opening and closing the permeation pathway (gating) in response to cGMP binding,
cyclic nucleotide-gated (CNG) channels serve key roles in the transduction of visual and …