Endogenous and exogenous sources cause free radical-induced DNA damage in living
organisms by a variety of mechanisms. The highly reactive hydroxyl radical reacts with the …

The most important electron acceptor in the biosphere is molecular oxygen which, by virtue
of its bi-radical nature, readily accepts unpaired electrons to give rise to a series of partially …

The linear-quadratic model is one of the key tools in radiation biology and physics. It
provides a simple relationship between cell survival and delivered dose:, and has been …

Publisher Summary This chapter provides a framework for understanding the way
permanent heritable damage in cellular DNA results from exposure to ionizing radiation. If …

A major portion of the toxicity of hydrogen peroxide in Escherichia coli is attributed to DNA
damage mediated by a Fenton reaction that generates active forms of hydroxyl radicals from …

Cells in tissues and organs are continuously subjected to oxidative stress and free radicals
on a daily basis. This free radical attack has exogenous or endogenous (intracellular) origin …

The importance of radical-induced damage to DNA is apparent from the ever-increasing
number of publications in this area. This review focuses on the damage caused to DNA by …

The accumulated evidence in the literature indicates that a cluster of two or more lesions
within one or two helical turns of the DNA is more challenging to repair than individual …

Efforts have been made to characterize and measure DNA modifications produced in
mammalian chromatin in vitro and in vivoby a variety of free radical-producing systems …

Although the DNA double-strand break (DSB) is defined as a rupture in the double-stranded
DNA molecule that can occur without chemical modification in any of the constituent building …