Blood flow in the microcirculation

TW Secomb - Annual Review of Fluid Mechanics, 2017 - annualreviews.org
The microcirculation is an extensive network of microvessels that distributes blood flow
throughout living tissues. Reynolds numbers are much less than 1, and the equations of …

Design and operation of magnetophoretic systems at microscale: device and particle approaches

WH Chong, SS Leong, JK Lim - Electrophoresis, 2021 - Wiley Online Library
Combining both device and particle designs are the essential concepts to be considered in
magnetophoretic system development. Researcher efforts are often dedicated to only one of …

Quantifying platelet margination in diabetic blood flow

HY Chang, A Yazdani, X Li, KAA Douglas… - Biophysical journal, 2018 - cell.com
Patients with type 2 diabetes mellitus (T2DM) develop thrombotic abnormalities strongly
associated with cardiovascular diseases. In addition to the changes of numerous …

Flow topology and targeted drug delivery in cardiovascular disease

SS Meschi, A Farghadan, A Arzani - Journal of Biomechanics, 2021 - Elsevier
Targeted drug delivery is a promising technique to direct the drug to the specific diseased
region. Nanoparticles have provided an attractive approach for this purpose. In practice, the …

Theory to predict particle migration and margination in the pressure-driven channel flow of blood

QM Qi, ESG Shaqfeh - Physical review fluids, 2017 - APS
The inhomogeneous concentration distribution of erythrocytes and platelets in microchannel
flows particularly in directions normal to the mean flow plays a significant role in hemostasis …

Sub-cellular modeling of platelet transport in blood flow through microchannels with constriction

A Yazdani, GE Karniadakis - Soft Matter, 2016 - pubs.rsc.org
Platelet transport through arterial constrictions is one of the controlling processes influencing
their adhesive functions and the formation of thrombi. We perform high-fidelity mesoscopic …

Nanoparticle transport in cellular blood flow

Z Liu, Y Zhu, RR Rao, JR Clausen, CK Aidun - Computers & Fluids, 2018 - Elsevier
The biotransport of the intravascular nanoparticle (NP) is influenced by both the complex
cellular flow environment and the NP characteristics. Being able to computationally simulate …

Red blood cell and platelet diffusivity and margination in the presence of cross-stream gradients in blood flows

G Závodszky, B van Rooij, B Czaja, V Azizi… - Physics of …, 2019 - pubs.aip.org
The radial distribution of cells in blood flow inside vessels is highly non-homogeneous. This
leads to numerous important properties of blood, yet the mechanisms shaping these …

The key events of thrombus formation: platelet adhesion and aggregation

T Ye, H Shi, N Phan-Thien, CT Lim - Biomechanics and modeling in …, 2020 - Springer
Thrombus formation is a complex, dynamic and multistep process, involving biochemical
reactions, mechanical stimulation, hemodynamics, and so on. In this study, we concentrate …

Nanoparticle diffusion in sheared cellular blood flow

Z Liu, JR Clausen, RR Rao, CK Aidun - Journal of Fluid Mechanics, 2019 - cambridge.org
Using a multiscale blood flow solver, the complete diffusion tensor of nanoparticles (NPs) in
sheared cellular blood flow is calculated over a wide range of shear rate and haematocrit. In …