Human topoisomerases and their roles in genome stability and organization
Y Pommier, A Nussenzweig, S Takeda… - … Reviews Molecular Cell …, 2022 - nature.com
Human topoisomerases comprise a family of six enzymes: two type IB (TOP1 and
mitochondrial TOP1 (TOP1MT), two type IIA (TOP2A and TOP2B) and two type IA (TOP3A …
mitochondrial TOP1 (TOP1MT), two type IIA (TOP2A and TOP2B) and two type IA (TOP3A …
Drugging topoisomerases: lessons and challenges
Y Pommier - ACS chemical biology, 2013 - ACS Publications
Topoisomerases are ubiquitous enzymes that control DNA supercoiling and entanglements.
They are essential during transcription and replication, and topoisomerase inhibitors are …
They are essential during transcription and replication, and topoisomerase inhibitors are …
Nuclear RNA-seq of single neurons reveals molecular signatures of activation
Single-cell sequencing methods have emerged as powerful tools for identification of
heterogeneous cell types within defined brain regions. Application of single-cell techniques …
heterogeneous cell types within defined brain regions. Application of single-cell techniques …
Tyrosyl-DNA-phosphodiesterases (tdp1 and tdp2)
TDP1 and TDP2 were discovered and named based on the fact they process 3′-and 5′-
DNA ends by excising irreversible protein tyrosyl-DNA complexes involving topoisomerases …
DNA ends by excising irreversible protein tyrosyl-DNA complexes involving topoisomerases …
Rationale for poly (ADP-ribose) polymerase (PARP) inhibitors in combination therapy with camptothecins or temozolomide based on PARP trapping versus catalytic …
We recently showed that poly (ADP-ribose) polymerase (PARP) inhibitors exert their
cytotoxicity primarily by trapping PARP-DNA complexes in addition to their NAD+ …
cytotoxicity primarily by trapping PARP-DNA complexes in addition to their NAD+ …
Involvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B viruses
C Königer, I Wingert, M Marsmann… - Proceedings of the …, 2014 - National Acad Sciences
Hepatitis B virus (HBV), the causative agent of chronic hepatitis B and prototypic
hepadnavirus, is a small DNA virus that replicates by protein-primed reverse transcription …
hepadnavirus, is a small DNA virus that replicates by protein-primed reverse transcription …
PARP1–TDP1 coupling for the repair of topoisomerase I–induced DNA damage
Abstract Poly (ADP-ribose) polymerases (PARP) attach poly (ADP-ribose)(PAR) chains to
various proteins including themselves and chromatin. Topoisomerase I (Top1) regulates …
various proteins including themselves and chromatin. Topoisomerase I (Top1) regulates …
Topoisomerase-mediated chromosomal break repair: an emerging player in many games
The mammalian genome is constantly challenged by exogenous and endogenous threats.
Although much is known about the mechanisms that maintain DNA and RNA integrity, we …
Although much is known about the mechanisms that maintain DNA and RNA integrity, we …
The dynamics and regulation of chromatin remodeling during spermiogenesis
SL Hao, FD Ni, WX Yang - Gene, 2019 - Elsevier
The functional sperm is the key factor for species continuation. The process
spermatogenesis, to produce mature sperm is quite complex. It begins with the proliferation …
spermatogenesis, to produce mature sperm is quite complex. It begins with the proliferation …
Debulking of topoisomerase DNA-protein crosslinks (TOP-DPC) by the proteasome, non-proteasomal and non-proteolytic pathways
Topoisomerases play a pivotal role in ensuring DNA metabolisms during replication,
transcription and chromosomal segregation. To manage DNA topology, topoisomerases …
transcription and chromosomal segregation. To manage DNA topology, topoisomerases …